Preprint Review Version 3 Preserved in Portico This version is not peer-reviewed

Chronic Pain Treated with the CMECD Procedure

Version 1 : Received: 4 February 2022 / Approved: 8 February 2022 / Online: 8 February 2022 (08:50:58 CET)
Version 2 : Received: 16 February 2022 / Approved: 17 February 2022 / Online: 17 February 2022 (10:46:17 CET)
Version 3 : Received: 26 February 2022 / Approved: 28 February 2022 / Online: 28 February 2022 (12:10:27 CET)

How to cite: Coletti, R.H. Chronic Pain Treated with the CMECD Procedure. Preprints 2022, 2022020104. Coletti, R.H. Chronic Pain Treated with the CMECD Procedure. Preprints 2022, 2022020104.


: This article was not intended to be a complete report of a standard clinical trial. It is a report of the outcomes of preliminary data for validation of the CMECD procedure (Coletti Method of EMG ChemoDenervation) protocol for the treatment of chronic pain resulting from chronic muscle spasm. Methods are here detailed on how to approach the patient with chronic pain, identify the presence of chronic muscle spasm, undertake the treatment protocol and how to perform the follow up process to confirm that chronic pain secondary to chronic muscle spasm was the accurate diagnosis. Furthermore, this article presents the results of a cohort of more than 90 patients treated by the CMECD procedure regarding location and duration of prior pain, prior treatment strategies, degree of success in resolving pain and duration of relief. Outcome data consisting of patient and staff reporting of specific situations in which the chronic pain treatment was successful has been included to help establish the “believability” of outcome successes and to elucidate the potential life altering effects of successful treatment of chronic pain secondary to chronic muscle spasm. This article will hopefully increase the interest in this treatment protocol and increase the chance that a classical international clinical trial will be undertaken.


EMG; muscle; spontaneous electrical activity (SEA); spasm; pain; CMECD protocol; phenoxybenzamine-lidocaine mixture


Medicine and Pharmacology, Orthopedics and Sports Medicine

Comments (1)

Comment 1
Received: 28 February 2022
Commenter: Roger Coletti
Commenter's Conflict of Interests: Author
Comment: Addition of raw data and statistical calculations
Interpretation of statistical findings
Re-organization of tables
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