Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Superstructure Detection in Nucleosome Distribution Shows Common Pattern within a Chromosome and within the Genome

Version 1 : Received: 26 January 2022 / Approved: 31 January 2022 / Online: 31 January 2022 (17:06:39 CET)

A peer-reviewed article of this Preprint also exists.

Mishra, S.K.; Li, K.; Brauburger, S.; Bhattacherjee, A.; Oiwa, N.N.; Heermann, D.W. Superstructure Detection in Nucleosome Distribution Shows Common Pattern within a Chromosome and within the Genome. Life 2022, 12, 541. Mishra, S.K.; Li, K.; Brauburger, S.; Bhattacherjee, A.; Oiwa, N.N.; Heermann, D.W. Superstructure Detection in Nucleosome Distribution Shows Common Pattern within a Chromosome and within the Genome. Life 2022, 12, 541.

Journal reference: Life 2022, 12, 541
DOI: 10.3390/life12040541

Abstract

Nucleosome positioning plays an important role in crucial biological processes like replication, transcription, and gene regulation. It has been widely used to predict the genome’s function and chromatin organisation. So far, the studies of patterns in nucleosome positioning have been limited to transcription start sites, CTCFs binding sites, and some promoter and loci regions. The genome-wide organisational pattern remains unknown. We have developed a theoretical model to coarse-grain nucleosome positioning data in order to obtain patterns in their distribution. Using hierarchical clustering on the auto-correlation function of this coarse-grained nucleosome positioning data, a genome-wide clustering is obtained for Candida albicans. The clustering shows the existence beyond hetero- and eu-chromatin inside the chromosomes.

Keywords

chromatin; nucleosome positioning; nucleosome distribution; heterochromatin; euchromatin; structure classification

Subject

BIOLOGY, Other

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