Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Pain Coping Strategies In Pediatric Patients With Acute Leukemias In The First Month Of Therapy: Effects Of Treatments And Implications On Procedural Analgesia

Marta Tremolada
* ORCID logo ,
Giulia Tasso
,
Roberta Maria Incardona
ORCID logo ,
Manuela Tumino
,
Maria Caterina Putti
,
Alessandra Biffi
,
Marta Pillon
ORCID logo
Version 1 : Received: 29 January 2022 / Approved: 31 January 2022 / Online: 31 January 2022 (11:43:26 CET)

A peer-reviewed article of this Preprint also exists.

Tremolada, M.; Tasso, G.; Incardona, R.M.; Tumino, M.; Putti, M.C.; Biffi, A.; Pillon, M. Pain Coping Strategies in Pediatric Patients with Acute Leukemias in the First Month of Therapy: Effects of Treatments and Implications on Procedural Analgesia. Cancers 2022, 14, 1473. Tremolada, M.; Tasso, G.; Incardona, R.M.; Tumino, M.; Putti, M.C.; Biffi, A.; Pillon, M. Pain Coping Strategies in Pediatric Patients with Acute Leukemias in the First Month of Therapy: Effects of Treatments and Implications on Procedural Analgesia. Cancers 2022, 14, 1473.

Abstract

Children with leukaemia experience difficulties adapting to medical procedures and to the chemotherapy’s adverse effects. Study’s objectives were to identify which coping strategies could be associated with the treatments’ factors and with the dosage of sedation analgesic drugs during bone marrow aspirates. 125 patients (M = 6.79 years; SD = 3.40), majority with acute lymphoblastic leukemia (90.4%) and their parents received, one month after diagnosis, the PPCI. Data on the severe treatment effects and on the dosage of drugs in sedation-analgesia were also collected. An ANCOVA model (R2=0.25) showed that, weighing the age factor (F=3.47; df=3; p=0.02), the number of episodes of fever (F=4.78; df=1; p=0.03), nausea (F=4.71; df=1; p=0.03) and mucositis (F=5.81; df=1; p=0.02) influenced the use of distraction. Cognitive self-instructions (R2=0.22) were influenced by the number of hospitalizations (F=5.14; df=1; p=0.03) and mucositis (F=8.48; df=3; p=0.004) and by child’s age (F=3.76; df=3; p=0.01). Children who sought parental support more frequently (F=9.7; df=2; p=0.0001) and who tended not to succumb to a catastrophic attitude (F=13.33; df=2; p=0.001) during the induction treatment phase required lower drug dosages, especially propofol. The clinical application of these results could be to encourage the use of cognitive self-instructions and search for social support.

Keywords

coping; pain; children; sedation; analgesia; treatment effects

Subject

Social Sciences, Psychology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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