Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Parenting and the Serotonin Transporter Gene (5HTTLPR), Which Association? A Systematic Review of the Literature

Marta Landoni
* ORCID logo ,
Alice Dalla Muta
,
Sonia Di Tella
,
Giulia Ciuffo
,
Paola Di Blasio
,
Chiara Ionio
ORCID logo
Version 1 : Received: 25 January 2022 / Approved: 26 January 2022 / Online: 26 January 2022 (12:19:45 CET)

A peer-reviewed article of this Preprint also exists.

Landoni, M.; Dalla Muta, A.; Di Tella, S.; Ciuffo, G.; Di Blasio, P.; Ionio, C. Parenting and the Serotonin Transporter Gene (5HTTLPR), Is There an Association? A Systematic Review of the Literature. Int. J. Environ. Res. Public Health 2022, 19, 4052. Landoni, M.; Dalla Muta, A.; Di Tella, S.; Ciuffo, G.; Di Blasio, P.; Ionio, C. Parenting and the Serotonin Transporter Gene (5HTTLPR), Is There an Association? A Systematic Review of the Literature. Int. J. Environ. Res. Public Health 2022, 19, 4052.

DOI: 10.3390/ijerph19074052

Abstract

The current systematic review examines whether there is an association between the genetic 5-HTTPLR pol-ymorphism and parenting and the mechanisms by which this association operates. The literature was searched in various databases such as PubMed, Scopus and ScienceDirect. In line with our inclusion criteria, nine articles were eligible out of 22. Most of the studies, analysed in this review, found an association between 5HTTLPR and parenting. Four studies found a direct association between 5-HTTLPR and parenting with conflicting findings: two studies found that mothers carrying the short variant were more sensitive to their infants, while two studies found that parents carrying the S allele were less sensitive. In addition, several studies found strong interaction between genetic and environmental factors, such as childhood stress and disruptive child behaviour, quality of early care experiences, poor parenting environment, and quality of environment. Only one study found an association between children’s 5HTTLPR and parenting. Parenting can be described as a highly complex construct influenced by multiple factors, including environmental, parenting and child charac-teristics. According to the studies, maternal 5-HTTLPR polymorphism is most likely associated with sensitive parenting.

Keywords

parenting; 5HTTLPR; serotonin transporter; maternal sensitivity; polymorphism; gene X environment

Subject

BEHAVIORAL SCIENCES, Clinical Psychology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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