Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Which Examination Is Most Useful in Assessing the Phenotype of Left Ventricular Noncompaction Cardiomyopathy in Children – Echocardiography, Cardiovascular Magnetic Resonance, or Both?

Version 1 : Received: 20 January 2022 / Approved: 24 January 2022 / Online: 24 January 2022 (13:59:45 CET)

A peer-reviewed article of this Preprint also exists.

Paszkowska, A.; Sarnecki, J.; Mirecka-Rola, A.; Kowalczyk-Domagała, M.; Mazurkiewicz, Ł.; Ziółkowska, L. Imaging Features of Pediatric Left Ventricular Noncompaction Cardiomyopathy in Echocardiography and Cardiovascular Magnetic Resonance. J. Cardiovasc. Dev. Dis. 2022, 9, 77. Paszkowska, A.; Sarnecki, J.; Mirecka-Rola, A.; Kowalczyk-Domagała, M.; Mazurkiewicz, Ł.; Ziółkowska, L. Imaging Features of Pediatric Left Ventricular Noncompaction Cardiomyopathy in Echocardiography and Cardiovascular Magnetic Resonance. J. Cardiovasc. Dev. Dis. 2022, 9, 77.

Journal reference: J. Cardiovasc. Dev. Dis. 2022, 9, 77
DOI: 10.3390/jcdd9030077

Abstract

Background: Left ventricular noncompaction (LVNC) is a distinct cardiomyopathy characterized by the presence of a two-layer myocardium with prominent trabeculation and deep intertrabecular recesses. The diagnosis of LVNC can be challenging because the diagnostic criteria are not uniform. The aim of our study was to evaluate echocardiographic and CMR findings in a group of children with isolated LVNC. Methods: From February 2008 to July 2021, pediatric patients under 18 years of age at the time of diagnosis with echocardiographic evidence of isolated LVNC were prospectively enrolled. The patients underwent echocardiography and contrast-enhanced cardiovascular magnetic resonance (CMR) with late gadolinium enhancement to assess myocardial noncompaction, ventricular size, and function. Results: A total of 34 patients with a median age of 11.9 years were recruited. Patients were followed prospectively for a median of 5.1 years. Of the 31 patients who met Jenni’s criteria in echocardiography, CMR was performed in 27 (79%). Further comprehensive analysis was performed in the group of 25 patients who met the echocardiographic and CMR criteria for LVNC. In echocardiography, the median NC/C ratio in systole was 2.60 and in diastole 3.40. In 25 out of 27 children (93%), LVNC was confirmed by CMR according to Petersen’s criteria, with a median NC/C ratio of 3.27. Conclusions: 1) Echocardiography precisely identifies patients with LVNC. 2) Echocardiography is a good method for monitoring LV systolic function, but CMR is indicated for the precise assessment of LV remodeling and RV size and function as well as for the detection of myocardial fibrosis.

Keywords

left ventricular noncompaction; cardiomyopathy; imaging; echocardiography; cardiovascular magnetic resonance; children

Subject

MEDICINE & PHARMACOLOGY, Pediatrics

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