Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

3D Printed Poly(?-Caprolactone)/Hydroxyapatite Scaffolds for Bone Tissue Engineering: A Comparative Study on Composite Preparation by Melt Blending or Solvent Casting Techniques and Influence of Bioceramic Content on Scaffold Properties

Version 1 : Received: 14 January 2022 / Approved: 17 January 2022 / Online: 17 January 2022 (11:29:33 CET)

A peer-reviewed article of this Preprint also exists.

Biscaia, S.; Branquinho, M.V.; Alvites, R.D.; Fonseca, R.; Sousa, A.C.; Pedrosa, S.S.; Caseiro, A.R.; Guedes, F.; Patrício, T.; Viana, T.; Mateus, A.; Maurício, A.C.; Alves, N. 3D Printed Poly(𝜀-caprolactone)/Hydroxyapatite Scaffolds for Bone Tissue Engineering: A Comparative Study on a Composite Preparation by Melt Blending or Solvent Casting Techniques and the Influence of Bioceramic Content on Scaffold Properties. Int. J. Mol. Sci. 2022, 23, 2318. Biscaia, S.; Branquinho, M.V.; Alvites, R.D.; Fonseca, R.; Sousa, A.C.; Pedrosa, S.S.; Caseiro, A.R.; Guedes, F.; Patrício, T.; Viana, T.; Mateus, A.; Maurício, A.C.; Alves, N. 3D Printed Poly(𝜀-caprolactone)/Hydroxyapatite Scaffolds for Bone Tissue Engineering: A Comparative Study on a Composite Preparation by Melt Blending or Solvent Casting Techniques and the Influence of Bioceramic Content on Scaffold Properties. Int. J. Mol. Sci. 2022, 23, 2318.

DOI: 10.3390/ijms23042318

Abstract

Bone tissue engineering has been developed in the past decades, with the engineering of bone substitutes on the vanguard of this regenerative approach. PCL based scaffolds are fairly applied for bone regeneration, and several composites have been incorporated, as to improve the devices’ mechanical properties and tissue ingrowth. In this study, HA was incorporated on PCL based scaffolds with two different proportions, 80:20 and 60:40. Devices were produced with two different techniques, SC and MB, and further investigated with regards to their mechanical characteristics and in vitro cytocompatibility. Results show the MB devices to present more promising mechanical properties, along with the incorporation of HA. The latter is also related to an increase in osteogenic activity and promotion. Overall, this study suggest PCL:HA scaffolds to be promising candidates for bone tissue engineering, particularly when produced by the MB method.

Keywords

Polycaprolactone; Hydroxyapatite; Composites; Solvent casting; Melt blending; 3D printing; Cytocompatibility; Bone tissue engineering

Subject

LIFE SCIENCES, Biotechnology

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