Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Examine the Association between Metabolic Syndrome and Frailty in an Older Asian Population

Version 1 : Received: 24 December 2021 / Approved: 29 December 2021 / Online: 29 December 2021 (12:09:59 CET)

A peer-reviewed article of this Preprint also exists.

Dao, H.H.H.; Nguyen, A.T.; Vu, H.T.T.; Nguyen, T.N. Examine the Association between Metabolic Syndrome and Frailty in an Older Asian Population. Diabetology 2022, 3, 108-116. Dao, H.H.H.; Nguyen, A.T.; Vu, H.T.T.; Nguyen, T.N. Examine the Association between Metabolic Syndrome and Frailty in an Older Asian Population. Diabetology 2022, 3, 108-116.

Journal reference: Diabetology 2022, 3, 9
DOI: 10.3390/diabetology3010009

Abstract

Background: There has been evidence that metabolic syndrome (MetS) may increase the risk of frailty. However, there is limited evidence on this association in Asian populations. Aims: This study aims to identify the association between MetS and frailty in older people in Vietnam. Methods: This is a cross-sectional analysis of a dataset obtained from an observational study on frailty and sarcopenia in patients aged ≥60 at a geriatric hospital in Vietnam. Frailty was defined by the frailty phenotype. Participants were defined as having MetS if they had ≥3 out of 5 criteria from the definition of the National Cholesterol Education Program (NCEP) Adults Treatment Panel (ATP) III. Multiple logistic regression models were performed to estimate the risk of having frailty in patients with MetS. Results: There were 669 participants (mean age 71, 60.2% female), 62.3% had MetS and 39.0% was frail. The prevalence of frailty was 42.2% in participants with MetS, 33.7% in participants without MetS (p=0.029). On logistic regression models, MetS was associated with increased likelihood of being frail (adjusted OR 1.52, 95%CI 1.01-2.28), allowing for age, sex, education, nutritional status, history of hospitalisation and chronic diseases. Conclusion: There was a significant association between MetS and frailty in this population. Further longitudinal studies are required to confirm this association.

Keywords

metabolic syndrome; diabetes; hypertension; obesity; frailty; older people; Asian

Subject

MEDICINE & PHARMACOLOGY, Cardiology

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