Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Genomic Comparative Analysis of Bacillus Coagulans Unravels the Genetic Potential of MA-13 Strain for Biotechnological Applications

Version 1 : Received: 20 December 2021 / Approved: 22 December 2021 / Online: 22 December 2021 (14:45:23 CET)

A peer-reviewed article of this Preprint also exists.

Aulitto, M.; Martinez-Alvarez, L.; Fiorentino, G.; Limauro, D.; Peng, X.; Contursi, P. A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications. Int. J. Mol. Sci. 2022, 23, 3135. Aulitto, M.; Martinez-Alvarez, L.; Fiorentino, G.; Limauro, D.; Peng, X.; Contursi, P. A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications. Int. J. Mol. Sci. 2022, 23, 3135.

Journal reference: Int. J. Mol. Sci. 2022, 23, 3135
DOI: 10.3390/ijms23063135

Abstract

The production of bio-chemicals requires the use of microbial strains with efficient substrate conversion and excellent environmental robustness, such as Bacillus coagulans spp. So far the genomes of about 50 strains have been sequenced. Herein, we report a comparative genomic analysis of nine strains on the full repertoire of CAZymes, secretion systems, and resistance mechanisms to environmental challenges. Moreover, B. coagulans Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) immune system along with CRISPR-associated Cas) genes, was also analysed. Overall, this study expands our understanding of the strains genomic diversity of B. coagulans to fully exploit its potential in biotechnological applications.

Keywords

B. coagulans; CAZymes; Bacteriocins; CRISPR-Cas systems.

Subject

BIOLOGY, Other

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