Submitted:
16 December 2021
Posted:
21 December 2021
You are already at the latest version
Abstract
A general approach to substituted pyrrolidines via [3 + 2] 1,3-dipolar cycloaddition between nonstabilized azomethine ylides and cyanosulfones was developed. The efficient method provides a series of substituted pyrrolidines bearing a quaternary carbon center in high yields (up to 98%) excellent diastereoselectivities (up to >25:1 dr) under ambient reaction conditions.
Keywords:
Pyrrolidines
; 1
; 3-dipolar cycloaddition
; azomethine ylides
; cyanosulfones
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