Version 1
: Received: 15 December 2021 / Approved: 16 December 2021 / Online: 16 December 2021 (08:12:13 CET)
How to cite:
Kutova, O.; Pospelov, A.; Balalaeva, I. The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintaining. Preprints2021, 2021120262. https://doi.org/10.20944/preprints202112.0262.v1
Kutova, O.; Pospelov, A.; Balalaeva, I. The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintaining. Preprints 2021, 2021120262. https://doi.org/10.20944/preprints202112.0262.v1
Kutova, O.; Pospelov, A.; Balalaeva, I. The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintaining. Preprints2021, 2021120262. https://doi.org/10.20944/preprints202112.0262.v1
APA Style
Kutova, O., Pospelov, A., & Balalaeva, I. (2021). The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintaining. Preprints. https://doi.org/10.20944/preprints202112.0262.v1
Chicago/Turabian Style
Kutova, O., Anton Pospelov and Irina Balalaeva. 2021 "The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintaining" Preprints. https://doi.org/10.20944/preprints202112.0262.v1
Abstract
The modern paradigm of studying the processes of carcinogenesis and vital activity of tumor tissues implies increased attention to constituents of tumor microenvironment (TME) and their interactions. These interactions between the cells in TME can be mediated via protein junctions of different types. Connexins (Cnxs) are one of the major contributors to intercellular communication. They form gap junctions responsible for the transfer of ions, metabolites, peptides, miRNA, etc. between neighboring tumor cells as well as between tumor and stromal cells. Cnx hemichannels mediate purinergic signaling and bidirectional molecular transport with the extracellular environment. Additionally, Cnxs were reported to localize in tumor-derived exosomes and facilitate the release of their cargo. A large body of evidence implies that the role of connexins in cancer is multifaceted. Pro- or anti-tumorigenic properties of connexins are determined by their abundance, localization and functionality as well as channel assembly and non-channel functions. In this review we have summarized the data on the Cnxs contribution in TME and to the cancer initiation and progression.
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
