Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintaining

Version 1 : Received: 15 December 2021 / Approved: 16 December 2021 / Online: 16 December 2021 (08:12:13 CET)

How to cite: Kutova, O.; Pospelov, A.; Balalaeva, I. The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintaining. Preprints 2021, 2021120262 (doi: 10.20944/preprints202112.0262.v1). Kutova, O.; Pospelov, A.; Balalaeva, I. The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintaining. Preprints 2021, 2021120262 (doi: 10.20944/preprints202112.0262.v1).

Abstract

The modern paradigm of studying the processes of carcinogenesis and vital activity of tumor tissues implies increased attention to constituents of tumor microenvironment (TME) and their interactions. These interactions between the cells in TME can be mediated via protein junctions of different types. Connexins (Cnxs) are one of the major contributors to intercellular communication. They form gap junctions responsible for the transfer of ions, metabolites, peptides, miRNA, etc. between neighboring tumor cells as well as between tumor and stromal cells. Cnx hemichannels mediate purinergic signaling and bidirectional molecular transport with the extracellular environment. Additionally, Cnxs were reported to localize in tumor-derived exosomes and facilitate the release of their cargo. A large body of evidence implies that the role of connexins in cancer is multifaceted. Pro- or anti-tumorigenic properties of connexins are determined by their abundance, localization and functionality as well as channel assembly and non-channel functions. In this review we have summarized the data on the Cnxs contribution in TME and to the cancer initiation and progression.

Keywords

tumor microenvironment; connexins; cell-cell contacts; tumor stroma; carcinogenesis; tumor development; metastasis

Subject

LIFE SCIENCES, Cell & Developmental Biology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.