Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Up-Conversion Nanomaterial Doped With Au Nanoparticles With Photothermal Conversion for Multi-Modality Imaging

Version 1 : Received: 11 December 2021 / Approved: 14 December 2021 / Online: 14 December 2021 (12:15:52 CET)

How to cite: Zhang, W.; Lu, Y.; Zang, Y.; Xiong, Q.; Xiong, J. Up-Conversion Nanomaterial Doped With Au Nanoparticles With Photothermal Conversion for Multi-Modality Imaging. Preprints 2021, 2021120233 (doi: 10.20944/preprints202112.0233.v1). Zhang, W.; Lu, Y.; Zang, Y.; Xiong, Q.; Xiong, J. Up-Conversion Nanomaterial Doped With Au Nanoparticles With Photothermal Conversion for Multi-Modality Imaging. Preprints 2021, 2021120233 (doi: 10.20944/preprints202112.0233.v1).

Abstract

In this study, a new method for synthesizing Au-NaYF4:Yb3+/Er3+-DSPE-PEG2K nanocomposites was introduced. Using a hydrothermal method, the synthesized Yb3+- and Er3+-codoped NaYF4 upconversion luminescent materials and Au nanoparticles were doped into upconversion nanomaterials and modified with DSPE-PEG2k up-conversion nanomaterials. This material is known as Ag-UCNPs-DSPE-PEG2k, it improves both the luminous intensity because of the doped Au nanoparticles and has low cytotoxicity because of the DSPE-PEG2k modified. Exciting UCNPs with a wavelength of 980nm near-infrared light will emit light with a wavelength of 520nm to further excite gold nanoparticles to convert light energy into heat. Successful synthesized gold nanoparticles was confirmed using transmission electron microscopy (TEM). The morphology of UCNPs was observed using scanning electron microscopy (SEM), and the mapping confirmed the successful doping of Au nanoparticles. Fluorescence spectra were used to compare changes in luminescence intensity before and after doping Au nanoparticles. The cytotoxicity of Au-UCNPs-DSPE-PEG2K was tested via the cell counting kit-8 (CCK-8) method, and its imaging ability was characterized using the Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) method.

Keywords

up-conversion; nanomaterials; photothermal conversion; multi-modality imaging

Subject

MATERIALS SCIENCE, Biomaterials

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