Version 1
: Received: 8 December 2021 / Approved: 10 December 2021 / Online: 10 December 2021 (15:08:53 CET)
How to cite:
Crisóstomo, T.; Pardal, M. A. E.; Herdy, S. A.; Muzi-Filho, H.; Mello, D. B.; Luzes, R.; Vieyra, A. Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats. Preprints2021, 2021120193. https://doi.org/10.20944/preprints202112.0193.v1
Crisóstomo, T.; Pardal, M. A. E.; Herdy, S. A.; Muzi-Filho, H.; Mello, D. B.; Luzes, R.; Vieyra, A. Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats. Preprints 2021, 2021120193. https://doi.org/10.20944/preprints202112.0193.v1
Crisóstomo, T.; Pardal, M. A. E.; Herdy, S. A.; Muzi-Filho, H.; Mello, D. B.; Luzes, R.; Vieyra, A. Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats. Preprints2021, 2021120193. https://doi.org/10.20944/preprints202112.0193.v1
APA Style
Crisóstomo, T., Pardal, M. A. E., Herdy, S. A., Muzi-Filho, H., Mello, D. B., Luzes, R., & Vieyra, A. (2021). Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats. Preprints. https://doi.org/10.20944/preprints202112.0193.v1
Chicago/Turabian Style
Crisóstomo, T., Rafael Luzes and Adalberto Vieyra. 2021 "Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats" Preprints. https://doi.org/10.20944/preprints202112.0193.v1
Abstract
Overweight/obesity is a growing pandemic nowadays that affects many organs and tissues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver alterations associated with previously described cardiovascular and kidney disturbances. Chronic administration of a high-lipid diet can provoke an hepatocardiorenal syndrome as the result of activation of the Ang II→type 1 receptor axis, which is completely counteracted by Ang-(3–4) the allosteric enhancer of the Ang II→type 2 receptor pathway.
Medicine and Pharmacology, Dietetics and Nutrition
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