Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats

Version 1 : Received: 8 December 2021 / Approved: 10 December 2021 / Online: 10 December 2021 (15:08:53 CET)

How to cite: Crisóstomo, T.; Pardal, M.A.E.; Herdy, S.A.; Muzi-Filho, H.; Mello, D.B.; Luzes, R.; Vieyra, A. Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats. Preprints 2021, 2021120193 (doi: 10.20944/preprints202112.0193.v1). Crisóstomo, T.; Pardal, M.A.E.; Herdy, S.A.; Muzi-Filho, H.; Mello, D.B.; Luzes, R.; Vieyra, A. Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats. Preprints 2021, 2021120193 (doi: 10.20944/preprints202112.0193.v1).

Abstract

Overweight/obesity is a growing pandemic nowadays that affects many organs and tissues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver alterations associated with previously described cardiovascular and kidney disturbances. Chronic administration of a high-lipid diet can provoke an hepatocardiorenal syndrome as the result of activation of the Ang II→type 1 receptor axis, which is completely counteracted by Ang-(3–4) the allosteric enhancer of the Ang II→type 2 receptor pathway.

Keywords

hyperlipidic diet; overweight rats; non-alcoholic liver steatosis; arterial hypertension; increased renal sodium reabsorption; hepatocardiorenal syndrome

Subject

MEDICINE & PHARMACOLOGY, Nutrition

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.