Version 1
: Received: 8 December 2021 / Approved: 10 December 2021 / Online: 10 December 2021 (15:08:53 CET)
How to cite:
Crisóstomo, T.; Pardal, M.A.E.; Herdy, S.A.; Muzi-Filho, H.; Mello, D.B.; Luzes, R.; Vieyra, A. Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats. Preprints2021, 2021120193 (doi: 10.20944/preprints202112.0193.v1).
Crisóstomo, T.; Pardal, M.A.E.; Herdy, S.A.; Muzi-Filho, H.; Mello, D.B.; Luzes, R.; Vieyra, A. Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats. Preprints 2021, 2021120193 (doi: 10.20944/preprints202112.0193.v1).
Cite as:
Crisóstomo, T.; Pardal, M.A.E.; Herdy, S.A.; Muzi-Filho, H.; Mello, D.B.; Luzes, R.; Vieyra, A. Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats. Preprints2021, 2021120193 (doi: 10.20944/preprints202112.0193.v1).
Crisóstomo, T.; Pardal, M.A.E.; Herdy, S.A.; Muzi-Filho, H.; Mello, D.B.; Luzes, R.; Vieyra, A. Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats. Preprints 2021, 2021120193 (doi: 10.20944/preprints202112.0193.v1).
Abstract
Overweight/obesity is a growing pandemic nowadays that affects many organs and tissues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver alterations associated with previously described cardiovascular and kidney disturbances. Chronic administration of a high-lipid diet can provoke an hepatocardiorenal syndrome as the result of activation of the Ang II→type 1 receptor axis, which is completely counteracted by Ang-(3–4) the allosteric enhancer of the Ang II→type 2 receptor pathway.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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