Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Multicomponent Materials to Improve Solubility: Eutectics of Drug Aminoglutethimide

Version 1 : Received: 29 November 2021 / Approved: 30 November 2021 / Online: 30 November 2021 (13:22:31 CET)

A peer-reviewed article of this Preprint also exists.

Saikia, B.; Seidel-Morgenstern, A.; Lorenz, H. Multicomponent Materials to Improve Solubility: Eutectics of Drug Aminoglutethimide. Crystals 2022, 12, 40. Saikia, B.; Seidel-Morgenstern, A.; Lorenz, H. Multicomponent Materials to Improve Solubility: Eutectics of Drug Aminoglutethimide. Crystals 2022, 12, 40.

Journal reference: Crystals 2021, 12, 40
DOI: 10.3390/cryst12010040

Abstract

Here, we report the synthesis and experimental characterization of three drug-drug eutectic mixtures of drug aminoglutethimide (AMG) with caffeine (CAF), nicotinamide (NIC) and ethenzamide (ZMD). The eutectic mixtures (AMG-CAF, AMG-NIC and AMG-ZMD) demonstrate significant melting point depressions ranging from 99.2 to 127.2 °C compared to the melting point of the drug AMG (151°C) and also show significantly higher aqueous solubilities than that of the AMG. The results presented include the determination of the binary melt phase diagrams and accompanying analytical characterization via X-ray powder diffraction, FT-IR spectroscopy and Scanning electron microscopy.

Keywords

Aminoglutethimide; Multicomponent solid form; Eutectic Mixure; Solubility

Subject

CHEMISTRY, Other

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