Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Host Restriction Factors Modulating HIV Latency and Replication in Myeloid Cells

Version 1 : Received: 20 November 2021 / Approved: 23 November 2021 / Online: 23 November 2021 (16:19:11 CET)

A peer-reviewed article of this Preprint also exists.

Pagani, I.; Demela, P.; Ghezzi, S.; Vicenzi, E.; Pizzato, M.; Poli, G. Host Restriction Factors Modulating HIV Latency and Replication in Macrophages. Int. J. Mol. Sci. 2022, 23, 3021. Pagani, I.; Demela, P.; Ghezzi, S.; Vicenzi, E.; Pizzato, M.; Poli, G. Host Restriction Factors Modulating HIV Latency and Replication in Macrophages. Int. J. Mol. Sci. 2022, 23, 3021.

Journal reference: Int. J. Mol. Sci. 2022, 23, 3021
DOI: 10.3390/ijms23063021

Abstract

In addition to CD4+ T lymphocytes, myeloid cells, and, particularly, differentiated macrophages, are targets of the human immunodeficiency virus type-1 (HIV-1) infection via interaction of gp120Env with CD4 and CCR5 or CXCR4. Both T cells and macrophages support virus replication although with substantial differences. In contrast to activated CD4+ T lymphocytes, HIV-1 replication in macrophages occurs in nondividing cells and it is characterized by virtual absence of cytopathicity both in vitro and in vivo. These general features should be considered in evaluating the role of cell-associated restriction factors aiming at preventing of curtailing virus replication in macrophages and T cells particularly in the context of designing strategies to tackle the viral reservoir in infected individuals receiving combination antiretroviral therapy. In this regard, we will here also discuss a model of reversible HIV-1 latency in primary human macrophages and the role of host factor determining restriction or reactivation of virus replication in myeloid cells.

Keywords

HIV; Macrophages; MDM; restriction factors; transcription factors; macrophage polarization

Subject

LIFE SCIENCES, Immunology

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