Version 1
: Received: 20 November 2021 / Approved: 22 November 2021 / Online: 22 November 2021 (11:43:15 CET)
How to cite:
Bermudez-Santana, C.I.; Gallego-Gómez, J.C. Toward a Taxonomy of Virus-ncRNAs Interactions in an RNA World for Disentangling Some Tiny Secrets of Dengue Virus. Preprints2021, 2021110385. https://doi.org/10.20944/preprints202111.0385.v1.
Bermudez-Santana, C.I.; Gallego-Gómez, J.C. Toward a Taxonomy of Virus-ncRNAs Interactions in an RNA World for Disentangling Some Tiny Secrets of Dengue Virus. Preprints 2021, 2021110385. https://doi.org/10.20944/preprints202111.0385.v1.
Cite as:
Bermudez-Santana, C.I.; Gallego-Gómez, J.C. Toward a Taxonomy of Virus-ncRNAs Interactions in an RNA World for Disentangling Some Tiny Secrets of Dengue Virus. Preprints2021, 2021110385. https://doi.org/10.20944/preprints202111.0385.v1.
Bermudez-Santana, C.I.; Gallego-Gómez, J.C. Toward a Taxonomy of Virus-ncRNAs Interactions in an RNA World for Disentangling Some Tiny Secrets of Dengue Virus. Preprints 2021, 2021110385. https://doi.org/10.20944/preprints202111.0385.v1.
Abstract
In recent years, the role of non-coding RNAs (ncRNAs) in regulating cell physiology has begun to be better understood. Recent discoveries in viral molecular biology have revealed that such cellular functions are disturbed during viral infections mainly due to host cell ncRNAs, cellular factors, and virus-derived ncRNAs. Apart from the interplay between those molecules, other interactions derive from the specific folding of RNA virus genomes. These fulfill canonical regulation functions such as replication, translation, and viral packaging. In some cases, folds serve as precursors of small viral RNAs whose biogenesis is not yet clearly understood. Since ncRNAs and RNA viral genomes modulate complex molecular and cellular processes in viral infections, a new taxonomy is being proposed here overarching three main categories, considering the current information about ncRNA interactions in some well-known viral infections. The first category shows examples of host ncRNAs associated with the trigger of the immune response under viral infections. The second category describes interactions between the virus and host ncRNAs. The last category shows how the shape of the RNA viral genome is essential in processing RNAs derived from viruses. Finally, we introduce evidence of how these three categories can also work as a framework in order to organize known interactions of ncRNAs and cellular factors under DENV infection. This new taxonomy of interactions provides a comprehensive framework for organizing the ncRNA regulatory roles in the context of viral interactions and an RNA world.
Keywords
n/aRNA genome; Viruses; host-viruses interactions; RNA world
Subject
LIFE SCIENCES, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
