Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Mast Cell Response to Leishmania mexicana and Sand Fly Salivary Proteins is Modulated by Androgens

Version 1 : Received: 19 November 2021 / Approved: 22 November 2021 / Online: 22 November 2021 (10:51:24 CET)

A peer-reviewed article of this Preprint also exists.

Sánchez-García, L.; Pérez-Torres, A.; Muñoz-Cruz, S.; Salaiza-Suazo, N.; Morales-Montor, J.; Becker, I. Mast-Cell Response to Leishmania mexicana and Sand-Fly Salivary Proteins Is Modulated by Orchiectomy. Pathogens 2022, 11, 398. Sánchez-García, L.; Pérez-Torres, A.; Muñoz-Cruz, S.; Salaiza-Suazo, N.; Morales-Montor, J.; Becker, I. Mast-Cell Response to Leishmania mexicana and Sand-Fly Salivary Proteins Is Modulated by Orchiectomy. Pathogens 2022, 11, 398.

Journal reference: Pathogens 2022, 11, 398
DOI: 10.3390/pathogens11040398

Abstract

Mast cells (MCs) play a crucial role during infections with Leishmania, that is transmitted through the bite of an infected sand fly that injects saliva together with the parasite. Sand fly saliva is a complex fluid that modulates the host immune response. In addition, hormonal factors modulate the host immune response, impacting the susceptibility to infections. Thus, to assess the impact of androgens and salivary proteins of sand fly vectors on the mast cell (MC) response to Leishmania infections, we infected orchiectomized male mice with the parasite in the presence or absence of sand fly salivary proteins and analyzed the inflammatory response of MCs. Our results showed a differential MC response to the parasite and to vector salivary proteins in mice deprived of gonadal hormones, as compared to sham-operated mice. Orchidectomy induced a different pattern of activation in MC of animals infected with Leishmania and vector-salivary proteins. Our results show that during Leishmania infection, androgens modulate the innate immunity response against the parasite and salivary proteins of the sand fly vector.

Keywords

Mast cells; Leishmania mexicana; sand fly salivary proteins; sexual hormones

Subject

LIFE SCIENCES, Microbiology

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