Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Effects of Dietary Fatty Acids on Gene Expression and Biological Processes in Different Tissues of Pigs: A Review

Simara Larissa Fanalli
,
Bruna Pereira Martins da Silva
,
Bruna Petry
,
Miguel Henrique de Almeida Santana
,
Guilherme Henrique Gebim Polizel
,
Robson Carlos Antunes
,
Vivian Vezzoni de Almeida
,
Gabriel Costa Monteiro Moreira
,
Albino Luchiari Filho
,
Luiz Lehmann Coutinho
,
Júlio Cesar de Carvalho Balieiro
,
James Mark Reecy
,
James Koltes
,
Dawn Koltes
,
Aline Silva Mello Cesar
*
Version 1 : Received: 7 November 2021 / Approved: 16 November 2021 / Online: 16 November 2021 (09:07:22 CET)

How to cite: Fanalli, S.L.; da Silva, B.P.M.; Petry, B.; Santana, M.H.D.A.; Polizel, G.H.G.; Antunes, R.C.; de Almeida, V.V.; Moreira, G.C.M.; Luchiari Filho, A.; Coutinho, L.L.; Balieiro, J.C.D.C.; Reecy, J.M.; Koltes, J.; Koltes, D.; Cesar, A.S.M. Effects of Dietary Fatty Acids on Gene Expression and Biological Processes in Different Tissues of Pigs: A Review. Preprints 2021, 2021110279. https://doi.org/10.20944/preprints202111.0279.v1 Fanalli, S.L.; da Silva, B.P.M.; Petry, B.; Santana, M.H.D.A.; Polizel, G.H.G.; Antunes, R.C.; de Almeida, V.V.; Moreira, G.C.M.; Luchiari Filho, A.; Coutinho, L.L.; Balieiro, J.C.D.C.; Reecy, J.M.; Koltes, J.; Koltes, D.; Cesar, A.S.M. Effects of Dietary Fatty Acids on Gene Expression and Biological Processes in Different Tissues of Pigs: A Review. Preprints 2021, 2021110279. https://doi.org/10.20944/preprints202111.0279.v1

Abstract

Studies on the influence of dietary components and their effects are fundamental for nutrigenomics, or the study of how nutrients can be cellular sensors, how they affect biological processes and gene expression in different tissues. Lipids are an important source of fatty acids (FA) and energy and are fundamental to biological processes and influence the regulation of transcription. Pigs are excellent model to study nutrigenomics, particularly lipid metabolism because the deposition and composition of FA in their tissues reflect the composition of FA in their diet. Recent studies show that FA supplementation is important in production systems, such as growing and finishing pigs, as it can improve the energy value of the feed, help reduce costs, improve animal welfare, and influence the nutritional value of the meat. Studies show that oleic (OA), linoleic (LA), docosahexaenoic (DHA), and eicosapentaenoic (EPA) acids are associated with the regulation of transcription in tissues such as muscle, liver, adipose tissue, and brain. Other studies indicate that EPA and DHA are associated with changes in specific signaling pathways, altering gene expression and biophysical properties of membranes. This review, therefore, focuses on the current knowledge of the effects of dietary FA on production traits and gene expression.

Keywords

animal model; dietary components; feeding strategy; gene expression; lipid profile; nutrients; nutrigenomic; physiological processes; signaling pathways; transcription.

Subject

Biology and Life Sciences, Animal Science, Veterinary Science and Zoology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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