Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Differential Spatial Distribution of TSPO or Amino Acid PET Signal and MRI Contrast Enhancement in Gliomas

Lena Kaiser
* ORCID logo ,
Adrien Holzgreve
ORCID logo ,
Stefanie Quach
,
Michael Ingrisch
,
Marcus Unterrainer
ORCID logo ,
Franziska J Dekorsy
,
Simon Lindner
,
Julia Brosch-Lenz
,
Astrid Delker
,
Guido Böning
,
Matthias Brendel
,
Rainer Rupprecht
,
Louisa von Baumgarten
,
Joerg C Tonn
,
Peter Bartenstein
,
Sibylle Ziegler
,
Nathalie L Albert
Version 1 : Received: 26 October 2021 / Approved: 1 November 2021 / Online: 1 November 2021 (16:02:58 CET)

A peer-reviewed article of this Preprint also exists.

Kaiser, L.; Holzgreve, A.; Quach, S.; Ingrisch, M.; Unterrainer, M.; Dekorsy, F.J.; Lindner, S.; Ruf, V.; Brosch-Lenz, J.; Delker, A.; Böning, G.; Suchorska, B.; Niyazi, M.; Wetzel, C.H.; Riemenschneider, M.J.; Stöcklein, S.; Brendel, M.; Rupprecht, R.; Thon, N.; von Baumgarten, L.; Tonn, J.-C.; Bartenstein, P.; Ziegler, S.; Albert, N.L. Differential Spatial Distribution of TSPO or Amino Acid PET Signal and MRI Contrast Enhancement in Gliomas. Cancers 2022, 14, 53. Kaiser, L.; Holzgreve, A.; Quach, S.; Ingrisch, M.; Unterrainer, M.; Dekorsy, F.J.; Lindner, S.; Ruf, V.; Brosch-Lenz, J.; Delker, A.; Böning, G.; Suchorska, B.; Niyazi, M.; Wetzel, C.H.; Riemenschneider, M.J.; Stöcklein, S.; Brendel, M.; Rupprecht, R.; Thon, N.; von Baumgarten, L.; Tonn, J.-C.; Bartenstein, P.; Ziegler, S.; Albert, N.L. Differential Spatial Distribution of TSPO or Amino Acid PET Signal and MRI Contrast Enhancement in Gliomas. Cancers 2022, 14, 53.

Abstract

In this study dual PET and contrast enhanced MRI were combined to investigate their correlation per voxel in patients at initial diagnosis with suspected glioblastoma. Correlation with contrast enhancement (CE) as an indicator of BBB leakage was further used to evaluate whether PET signal is likely caused by BBB disruption alone, or rather attributable to specific binding after BBB passage. PET images with [18F]GE180 and the amino acid [18F]FET were acquired and normalized to healthy background (TBR). Contrast enhanced images were normalized voxel by voxel with the pre-contrast T1-weighted MRI to generate relative CE values (rCE). Voxel-wise analysis revealed a high PET signal even within the sub-volumes without detectable CE. No to moderate correlation of rCE with TBR voxel-values and a small overlap as well as a larger distance of the hotspots delineated in rCE and TBR-PET images were detected. In contrast, voxel-wise correlation between both PET modalities was strong for most patients and hotspots showed a moderate overlap and distance. The high PET signal in tumor sub-volumes without CE observed in voxel-wise analysis as well as the discordant hotspots emphasize the specificity of the PET signals and the relevance of combined differential information from dual PET and MRI images.

Keywords

TSPO PET; amino acid PET; FET PET; glioma; contrast enhancement; spatial correlation

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.