Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications

Version 1 : Received: 2 October 2021 / Approved: 5 October 2021 / Online: 5 October 2021 (08:20:44 CEST)

How to cite: Puła, A.; Robak, P.; Mikulski, D.; Robak, T. The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications. Preprints 2021, 2021100069 (doi: 10.20944/preprints202110.0069.v1). Puła, A.; Robak, P.; Mikulski, D.; Robak, T. The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications. Preprints 2021, 2021100069 (doi: 10.20944/preprints202110.0069.v1).

Abstract

Multiple myeloma (MM) is a genetically complex disease that results from a multistep transformation of normal to malignant plasma cells in the bone marrow. However, the molecular mechanisms responsible for the initiation and heterogeneous evolution of MM remain largely unknown. A fundamental step needed to understand the oncogenesis of MM and its response to therapy is the identification of driver mutations. The introduction of gene expression profiling (GEP) in MM was an important step in elucidating the molecular heterogeneity of MM and its clinical relevance. Since some mutations in myeloma occur in non-coding regions, studies based on the analysis of mRNA provide more comprehensive information on the oncogenic pathways and mechanisms relevant to MM biology. In this review, we discuss the role of gene expression profiling in understanding the biology of multiple myeloma together with the clinical manifestation of the disease, as well as its impact on treatment decisions and future directions.

Keywords

biology; drug resistance; gene expression profiling; mRNA; multiple myeloma; prognosis; treatment

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