Working Paper Review Version 1 This version is not peer-reviewed

Comparative Functions of the Endogenous Neural Stem Cell Secretome Across Species through Neurodevelopment and Disease

Version 1 : Received: 1 October 2021 / Approved: 4 October 2021 / Online: 4 October 2021 (12:25:30 CEST)

How to cite: Dause, T.; Denninger, J.; Smith, B.; Kirby, E. Comparative Functions of the Endogenous Neural Stem Cell Secretome Across Species through Neurodevelopment and Disease. Preprints 2021, 2021100058 Dause, T.; Denninger, J.; Smith, B.; Kirby, E. Comparative Functions of the Endogenous Neural Stem Cell Secretome Across Species through Neurodevelopment and Disease. Preprints 2021, 2021100058

Abstract

Neural stem cell (NSC) based therapies are at the forefront of regenerative medicine strategies to combat illness and injury of the central nervous system (CNS). In addition to their ability to produce new cells, NSCs secrete a variety of products, known as the NSC secretome, that have been shown to ameliorate CNS disease pathology and promote recovery. As pre-clinical and clinical research to harness the NSC secretome for therapeutic purposes advances, a more thorough understanding of the endogenous NSC secretome can provide useful insight into the functional capabilities of NSCs. In this review, we focus on research investigating the autocrine and paracrine functions of the endogenous NSC secretome across life. We also compare the NSC secretome across species, finding signs of conserved parallels between rodent, human and zebrafish NSC secretomes. Throughout development and adulthood, we find evidence that the NSC secretome is a critical component of how endogenous NSCs regulate themselves and their niche. We also find gaps in current literature, most notably in the clinically relevant domain of endogenous NSC paracrine function in the injured CNS. Future investigations to further define the endogenous NSC secretome and its role in CNS tissue regulation are necessary to bolster our understanding of NSC-niche interactions and to aid in the generation of safe and effective NSC-based therapies.

Keywords

Neural Stem Cell; Secretome; Neurodevelopment; Radial Glia; Neural Progenitor Cell

Subject

LIFE SCIENCES, Cell & Developmental Biology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.