Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Measurement of Adult Human Brain Responses to Breath Holding by Multi-Distance Hyperspectral Near-Infrared Spectroscopy

Version 1 : Received: 26 September 2021 / Approved: 29 September 2021 / Online: 29 September 2021 (10:50:12 CEST)

How to cite: Guerouah, Z.; Lin, S.; Toronov, V. Measurement of Adult Human Brain Responses to Breath Holding by Multi-Distance Hyperspectral Near-Infrared Spectroscopy. Preprints 2021, 2021090487 (doi: 10.20944/preprints202109.0487.v1). Guerouah, Z.; Lin, S.; Toronov, V. Measurement of Adult Human Brain Responses to Breath Holding by Multi-Distance Hyperspectral Near-Infrared Spectroscopy. Preprints 2021, 2021090487 (doi: 10.20944/preprints202109.0487.v1).

Abstract

A major limitation of near-infrared spectroscopy (NIRS) is its high sensitivity to the scalp and low sensitivity to the brain of adult humans. In the present work we use multi-distance hyperspectral NIRS (hNIRS) to investigate the optimal source-detector distances, range of wavelengths, and analysis techniques to separate cerebral responses to 30-s breath holds (BHs) from the responses in the superficial tissue layer in healthy adult humans. We observed significant responses to BHs in the scalp hemodynamics. Cerebral responses to BHs were detected in the cytochrome C oxidase redox (rCCO) at 4 cm without using data from the short-distance channel. Using the data from the 1 cm channel in the two-layer regression algorithm showed that hemodynamic and rCCO responses also occurred at 3cm. We found that the waveband 700-900 nm was optimal for the detection of cerebral responses to BHs in adults.

Keywords

near-infrared spectroscopy; brain; BOLD signal; breath holding; cytochrome C oxidase

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