Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Predictive Test of Outflow Enhancement by Ab Interno Trabeculectomy

Version 1 : Received: 20 September 2021 / Approved: 20 September 2021 / Online: 20 September 2021 (16:34:00 CEST)

How to cite: Verma-Fuehring, R.; Dakroub, M.; Han, H.; Hillenkamp, J.; A. Loewen, N. A Predictive Test of Outflow Enhancement by Ab Interno Trabeculectomy. Preprints 2021, 2021090346 (doi: 10.20944/preprints202109.0346.v1). Verma-Fuehring, R.; Dakroub, M.; Han, H.; Hillenkamp, J.; A. Loewen, N. A Predictive Test of Outflow Enhancement by Ab Interno Trabeculectomy. Preprints 2021, 2021090346 (doi: 10.20944/preprints202109.0346.v1).

Abstract

Purpose: To investigate trabeculopuncture (TP) for predicting the outcome of ab interno trabeculectomy (AIT). AIT is an effective, low-risk procedure for open angle glaucoma. Despite widespread utilization, it fails in patients with an unidentified distal outflow resistance. Methods: We bisected 81 enucleated porcine eyes and perfused them for 72 hours. They were assigned to two groups: trial (n=42) and control (n=39). Intraocular pressure (IOP) was measured continuously. At 24 hours, four YAG-laser trabeculopunctures on the nasal trabecular meshwork were performed, followed by a 180° AIT at the same site at 48 hours. Eyes were divided into TP and AIT responders and non-responders; the proportion of TP responders between both AIT groups was compared. Results: Both post-TP and post-AIT IOPs were lower than baseline IOP (p=0.015 and p<0.01, respectively). The success rates of TP and AIT were 69% and 85.7%, respectively. The proportion of TP responders among AIT responders was greater than that of AIT non-responders (p<0.01). Sensitivity and specificity values of TP as predictive test for AIT success were 77.7% and 83.3%, respectively. The positive and negative predictive values were 96.6% and 38.5%, respectively. Conclusion: A 10% reduction in IOP after TP can be used as predictor for the success (>20% IOP decrease) of 180° AIT in porcine eyes.

Keywords

goniopuncture; ab interno trabeculectomy; porcine eyes; glaucoma; predictive test

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