Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Genistein Mediated Molecular Pharmacology, Cell-Specific Anti-Breast Cancer Mechanism with Synergistic Effect and in silico Safety Measurement

Version 1 : Received: 7 September 2021 / Approved: 7 September 2021 / Online: 7 September 2021 (11:59:15 CEST)

How to cite: Sohel, M.; Biswas, P.; Al Amin, M.; Dey, D.; Sultana, H.; Aktar, S.; Khan, M.S.; Hossain, M.A.; Paul, P.; Md. Nurul, I.; Rahman, M.A.; Kim, B.; Al Mamun, A. Genistein Mediated Molecular Pharmacology, Cell-Specific Anti-Breast Cancer Mechanism with Synergistic Effect and in silico Safety Measurement. Preprints 2021, 2021090123 (doi: 10.20944/preprints202109.0123.v1). Sohel, M.; Biswas, P.; Al Amin, M.; Dey, D.; Sultana, H.; Aktar, S.; Khan, M.S.; Hossain, M.A.; Paul, P.; Md. Nurul, I.; Rahman, M.A.; Kim, B.; Al Mamun, A. Genistein Mediated Molecular Pharmacology, Cell-Specific Anti-Breast Cancer Mechanism with Synergistic Effect and in silico Safety Measurement. Preprints 2021, 2021090123 (doi: 10.20944/preprints202109.0123.v1).

Abstract

Breast cancer (BC) is the most common type of cancer in both men and women alike, but it is more prevalent in women. Natural compounds that can modulate the oncogenic process can be considered a significant anti-cancer agent for treating BC. These natural compounds are more effective than synthetic drugs, which have profound side effects on the normal cell and resistance to cancer cells. Genistein is a type of dietary phytoestrogen included in the flavonoid group with a similar structure of estrogen that might provide a strong alternative and complementary medicine to existing chemotherapeutics drugs. Several research studies demonstrated that it can target the estrogen receptor (ER), Human epidermal growth factor receptor-2 (HER2), and Breast cancer gene-1 (BRCA-1) in multiple BC cell lines, as well as sensitize cancer cell lines to this compound when used at an optimal inhibitory concentration. Genistein effectively showed anti-cancer activities through apoptosis induction, arresting cell cycle, inhibiting angiogenesis with metastasis, reducing inflammation, mammosphere formation, tumor growth, up-regulating tumor suppressor gene, and downregulating oncogene in suppressing cancer progression in vitro and animal model study. In addition, research studies have also suggested that these phytochemicals synergistically reverse the resistance mechanism of chemotherapeutic drugs, increasing the efficacy of some chemoinformatics drugs. Our review article aims to unbox and validate the molecular pharmacology in breast tissue, cell-specific anti-cancer mechanism with synergistic activity, and possible pharmacokinetic parameters of Genistein as a potential alternative therapeutic option for the treatment of BC.

Keywords

Genistein; Estrogen receptor; BRCA-1; Cell cycle; Tumor suppressor gene; Molecular pharmacology; Synergistic activity.

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.