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How Viruses Use the VCP/p97 ATPase Molecular Machine
Version 1
: Received: 26 August 2021 / Approved: 30 August 2021 / Online: 30 August 2021 (12:06:29 CEST)
A peer-reviewed article of this Preprint also exists.
Das, P.; Dudley, J.P. How Viruses Use the VCP/p97 ATPase Molecular Machine. Viruses 2021, 13, 1881. Das, P.; Dudley, J.P. How Viruses Use the VCP/p97 ATPase Molecular Machine. Viruses 2021, 13, 1881.
Abstract
Viruses are obligate intracellular parasites that are dependent on host factors for their replication. One such host protein, p97 or the valosin-containing protein (VCP), is a highly conserved AAA ATPase that facilitates replication of diverse RNA- and DNA-containing viruses. The wide range of cellular functions attributed to this ATPase is consistent with its participation in multiple steps of the virus life cycle from entry and uncoating to viral egress. Studies of VCP/p97 interactions with viruses will provide important information about host processes and cell biology, but also viral strategies that take advantage of these host functions. The critical role of p97 in viral replication might be exploited as a target for development of pan-antiviral drugs that exceed the capability of virus-specific vaccines or therapeutics.
Keywords
VCP; p97; virus replication; ERAD; cellular trafficking; uncoating; egress; antiviral immune response; retrotranslocation
Subject
Biology and Life Sciences, Virology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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