Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Hodgkin Lymphoma in People Living With HIV

Version 1 : Received: 20 August 2021 / Approved: 20 August 2021 / Online: 20 August 2021 (14:08:47 CEST)

A peer-reviewed article of this Preprint also exists.

Navarro, J.-T.; Moltó, J.; Tapia, G.; Ribera, J.-M. Hodgkin Lymphoma in People Living with HIV. Cancers 2021, 13, 4366. Navarro, J.-T.; Moltó, J.; Tapia, G.; Ribera, J.-M. Hodgkin Lymphoma in People Living with HIV. Cancers 2021, 13, 4366.


Despite widespread use of combined antiretroviral therapy (cART) and increased life expectancy in people living with HIV (PLWH), HIV-related lymphomas (HRL) remain a leading cause of cancer morbidity and mortality for PLWH, even in patients optimally treated with cART. While incidence of aggressive forms of non-Hodgkin lymphoma decreased after cART advent, incidence of Hodgkin lymphoma (HL) has increased among PLWH in recent decades. The coinfection of Epstein Barr virus plays a crucial role in the pathogenesis of HL in the HIV setting. Currently, PLWH with HRL, including HL, are treated similarly to HIV-negative patients and, importantly, the prognosis of HL in PLWH is approaching to that of the general population. In this regard, effective chem-otherapy is strongly recommended since it has been shown to improve survival rates in all lymphoma subtypes, including HL. As a consequence, interdisciplinary collaboration between HIV specialists and hemato-oncologists for the management of potential drug-drug interactions and overlapping toxicities between antiretroviral and antineoplastic drugs is crucial for the op-timal treatment of PLWH with HL. In this article the authors review and update the epidemio-logical, clinical and biological aspects of HL presenting in PLWH with special emphasis in the improvement on prognosis and the factors that have contributed to it.


Hodgkin lymphoma, HIV,; antiretroviral therapy; prognosis; etiopathogenesis


Medicine and Pharmacology, Oncology and Oncogenics

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