Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Hodgkin Lymphoma in People Living With HIV

Version 1 : Received: 20 August 2021 / Approved: 20 August 2021 / Online: 20 August 2021 (14:08:47 CEST)

A peer-reviewed article of this Preprint also exists.

Navarro, J.-T.; Moltó, J.; Tapia, G.; Ribera, J.-M. Hodgkin Lymphoma in People Living with HIV. Cancers 2021, 13, 4366. Navarro, J.-T.; Moltó, J.; Tapia, G.; Ribera, J.-M. Hodgkin Lymphoma in People Living with HIV. Cancers 2021, 13, 4366.

Abstract

Despite widespread use of combined antiretroviral therapy (cART) and increased life expectancy in people living with HIV (PLWH), HIV-related lymphomas (HRL) remain a leading cause of cancer morbidity and mortality for PLWH, even in patients optimally treated with cART. While incidence of aggressive forms of non-Hodgkin lymphoma decreased after cART advent, incidence of Hodgkin lymphoma (HL) has increased among PLWH in recent decades. The coinfection of Epstein Barr virus plays a crucial role in the pathogenesis of HL in the HIV setting. Currently, PLWH with HRL, including HL, are treated similarly to HIV-negative patients and, importantly, the prognosis of HL in PLWH is approaching to that of the general population. In this regard, effective chem-otherapy is strongly recommended since it has been shown to improve survival rates in all lymphoma subtypes, including HL. As a consequence, interdisciplinary collaboration between HIV specialists and hemato-oncologists for the management of potential drug-drug interactions and overlapping toxicities between antiretroviral and antineoplastic drugs is crucial for the op-timal treatment of PLWH with HL. In this article the authors review and update the epidemio-logical, clinical and biological aspects of HL presenting in PLWH with special emphasis in the improvement on prognosis and the factors that have contributed to it.

Keywords

Hodgkin lymphoma, HIV,; antiretroviral therapy; prognosis; etiopathogenesis

Subject

Medicine and Pharmacology, Oncology and Oncogenics

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