Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Virulence factors of Enteric Pathogenic Escherichia coli: A Review

Version 1 : Received: 15 August 2021 / Approved: 17 August 2021 / Online: 17 August 2021 (08:16:59 CEST)

A peer-reviewed article of this Preprint also exists.

Pakbin, B.; Brück, W.M.; Rossen, J.W.A. Virulence Factors of Enteric Pathogenic Escherichia coli: A Review. Int. J. Mol. Sci. 2021, 22, 9922. Pakbin, B.; Brück, W.M.; Rossen, J.W.A. Virulence Factors of Enteric Pathogenic Escherichia coli: A Review. Int. J. Mol. Sci. 2021, 22, 9922.

Journal reference: Int. J. Mol. Sci. 2021, 22, 9922
DOI: 10.3390/ijms22189922

Abstract

Abstract: Escherichia coli are remarkably versatile microorganisms and important members of the normal intestinal microbiota of humans and animals. This harmless commensal organism can acquire a mixture of comprehensive mobile genetic elements that contain genes encoding viru-lence factors, becoming an emerging human pathogen capable of causing a broad spectrum of intestinal and extraintestinal diseases. Nine definite enteric E. coli pathotypes have been well characterized, causing diseases ranging from various gastrointestinal disorders to urinary tract infections. These pathotypes employ many virulence factors and effectors subverting the func-tions of host cells to mediate its virulence and pathogenesis. This review summarizes new de-velopments in our understanding of diverse virulence factors associated encoding genes used by different pathotypes of enteric pathogenic E. coli to cause intestinal and extraintestinal diseases in humans.

Keywords

Enteric pathogenic Escherichia coli; E. coli pathotypes; Virulence factor genes

Subject

LIFE SCIENCES, Microbiology

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