Working Paper Review Version 2 This version is not peer-reviewed

EHMT2/G9a as an Epigenetic Target in Pediatric and Adult Brain Tumors

Version 1 : Received: 13 August 2021 / Approved: 16 August 2021 / Online: 16 August 2021 (12:31:31 CEST)
Version 2 : Received: 6 October 2021 / Approved: 8 October 2021 / Online: 8 October 2021 (10:57:22 CEST)

How to cite: Souza, B.K.; Freire, N.H.; Jaeger, M.; de Farias, C.B.; Brunetto, A.L.; Brunetto, A.T.; Roesler, R. EHMT2/G9a as an Epigenetic Target in Pediatric and Adult Brain Tumors. Preprints 2021, 2021080335 Souza, B.K.; Freire, N.H.; Jaeger, M.; de Farias, C.B.; Brunetto, A.L.; Brunetto, A.T.; Roesler, R. EHMT2/G9a as an Epigenetic Target in Pediatric and Adult Brain Tumors. Preprints 2021, 2021080335

Abstract

Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during normal development, and are also involved in carcinogenesis and cancer progression. The histone methyltransferase G9a (euchromatic histone lysine methyltransferase 2, EHMT2), which mostly mediates mono- and dimethylation by histone H3 lysine 9 (H3K9), influences gene expression involved in embryonic development and tissue differentiation. Overexpression of G9a has been observed in several cancer types, and different classes of G9a inhibitors have been developed as potential anticancer agents. Here, we review the emerging evidence suggesting the involvement of changes in G9a activity in brain tumors, namely glioblastoma (GBM), the main type of primary malignant brain cancer in adults, and medulloblastoma (MB), the most common type of malignant brain cancer in children. We also discuss the role of G9a in neuroblastoma (NB) and the drug development of G9a inhibitors.

Keywords

G9a; EHMT2; glioblastoma; medulloblastoma; epigenetics; brain tumor

Subject

LIFE SCIENCES, Molecular Biology

Comments (1)

Comment 1
Received: 8 October 2021
Commenter: Rafael Roesler
Commenter's Conflict of Interests: Author
Comment: The manuscript was edited and the experimental data reported in the previous version was removed from the text, figures, and legends, as required by two reviewers. 
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