Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Design and Synthesis of Novel Peptides to Protect Ferulic Acid Against Ultraviolet Radiation Based on Domain Site IIA of Bovine Serum Albumin

Version 1 : Received: 12 August 2021 / Approved: 13 August 2021 / Online: 13 August 2021 (08:48:39 CEST)

A peer-reviewed article of this Preprint also exists.

Wu, Y.; Farrag, H.N.; Kato, T.; Li, H.; Ikeno, S. Design and Synthesis of Novel Peptides to Protect Ferulic Acid against Ultraviolet Radiation Based on Domain Site IIA of Bovine Serum Albumin. Biomolecules 2021, 11, 1285. Wu, Y.; Farrag, H.N.; Kato, T.; Li, H.; Ikeno, S. Design and Synthesis of Novel Peptides to Protect Ferulic Acid against Ultraviolet Radiation Based on Domain Site IIA of Bovine Serum Albumin. Biomolecules 2021, 11, 1285.

Journal reference: Biomolecules 2021, 11, 1285
DOI: 10.3390/biom11091285

Abstract

Ferulic acid (FA) is known for its excellent antioxidant properties that can provide a lot of health benefits. One of its drawbacks is being unstable under UVA light that limits its potency. In this study, new peptides LW2 (QNKRFYFRKNQ) and CW2 (a cyclic form of LW2) have been designed based on bovine serum albumin site ⅡA conformation. UVA irradiation experiment was performed to investigate the protective ability of these peptides towards FA against UVA damage. The percentage of FA remaining under UV irradiation by the protection of CW2 and LW2 was 83%, 76% respectively. The results showed the importance of the cationic residues and hydrophobic residues included in the peptide sequences. Moreover, the cyclic rigid structure showed more protecting ability over that of the linear counterpart.

Keywords

ferulic acid; UVA light; cyclic peptide; bovine serum albumin

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