Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Resorbable Mg2+-Containing Phosphates for Bone Tissue Repair

Version 1 : Received: 10 August 2021 / Approved: 11 August 2021 / Online: 11 August 2021 (10:41:43 CEST)

A peer-reviewed article of this Preprint also exists.

Kazakova, G.; Safronova, T.; Golubchikov, D.; Shevtsova, O.; Rau, J.V. Resorbable Mg2+-Containing Phosphates for Bone Tissue Repair. Materials 2021, 14, 4857. Kazakova, G.; Safronova, T.; Golubchikov, D.; Shevtsova, O.; Rau, J.V. Resorbable Mg2+-Containing Phosphates for Bone Tissue Repair. Materials 2021, 14, 4857.

Journal reference: Materials 2021, 14, 4857
DOI: 10.3390/ma14174857

Abstract

Materials based on Mg2+-containing phosphates are gaining great relevance in the field of bone tissue repair via regenerative medicine methods. Magnesium ions, together with condensed phosphate ions, play a significant role in the process of bone remodeling, affecting the early stage of bone regeneration through active participation in the process of osteosynthesis. Here we pro-vide a comprehensive overview of the usage of biomaterials based on magnesium phosphate and magnesium calcium phosphate in bone reconstruction. The role of magnesium ions in angiogene-sis, an important process associated with osteogenesis, is considered. Finally, the biological properties of magnesium phosphates for bone regeneration are summarized. They show promis-ing results in terms of use as bone replacement material.

Keywords

whitlockite; calcium magnesium phosphates; struvite; newberrite; bone reconstruction; resorba-bility; bioactivity; orthopedic applications

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