Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

New Metabolic and Genetic Biomarkers for Diagnosis of Ulcerative Colitis

Version 1 : Received: 1 August 2021 / Approved: 2 August 2021 / Online: 2 August 2021 (14:39:13 CEST)

How to cite: Tudoroniu, E.E.; Costache, M.A.; Stancu, M.; Pop, A.L. New Metabolic and Genetic Biomarkers for Diagnosis of Ulcerative Colitis. Preprints 2021, 2021080048 (doi: 10.20944/preprints202108.0048.v1). Tudoroniu, E.E.; Costache, M.A.; Stancu, M.; Pop, A.L. New Metabolic and Genetic Biomarkers for Diagnosis of Ulcerative Colitis. Preprints 2021, 2021080048 (doi: 10.20944/preprints202108.0048.v1).

Abstract

Ulcerative colitis (UC) is one of the two disorders known as inflammatory bowel diseases (IBD) along with Crohn’s disease (CD), with complex pathogenesis, requiring costly invasive investigations. Objective: to examine the most recent biomarkers proposed for UC diagnosis; to establish the strategy used to make the differential diagnosis between UC and CD relying on these biomarkers, also adding the benefit of finding new non-invasive tools in managing this condition. The search was performed in a single database (Web of Science) using the specific keywords „ulcerative colitis”, „biomarkers” and „diagnosis” for the last five years. Study eligibility criteria: clinical trials on adults and pediatric patients with ulcerative colitis compared with Crohn’s disease. Results: We selected 57 studies, randomized controlled trials (RCTs) and clinical case series (CCS), summarizing the latest most specific biomarkers in diagnosis of UC. Limitations: we considered RCTs and CCS from one database, limited to the search topics. Our findings indicate a important number of potential biomarkers with diagnostic value, which bring the advantage of a non-invasive method to approach this challenging disorder.

Keywords

ulcerative colitis; biomarkers; diagnosis; inflammatory bowel disease; Crohn’s disease

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