Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Microbiome First Medicine in Health and Safety

Version 1 : Received: 27 July 2021 / Approved: 29 July 2021 / Online: 29 July 2021 (11:37:20 CEST)

A peer-reviewed article of this Preprint also exists.

Dietert, R.R. Microbiome First Medicine in Health and Safety. Biomedicines 2021, 9, 1099. Dietert, R.R. Microbiome First Medicine in Health and Safety. Biomedicines 2021, 9, 1099.

Journal reference: Biomedicines 2021, 9, 1099
DOI: 10.3390/biomedicines9091099

Abstract

Microbiome First Medicine is a suggested 21st century healthcare paradigm that prioritizes the entire human, the human superorganism, beginning with the microbiome. To date, much of medicine has protected and treated patients as if they were a single species. This has resulted in unintended damage to the microbiome and an epidemic of chronic disorders [e.g., noncommunicable diseases and conditions (NCDs)]. Along with NCDs came loss of colonization re-sistance, increased susceptibility to infectious diseases, and increasing multimorbidity and polypharmacy over the life course. To move toward sustainable healthcare, the human micro-biome needs to be front and center. This paper presents microbiome-human physiology from the view of systems biology regulation. It also details the ongoing NCD epidemic including the role of existing drugs and other factors that damage the human microbiome. Examples are provided for two entryway NCDs, asthma and obesity, regarding their extensive network of comorbid NCDs. Finally, the challenges of ensuring safety for the microbiome are detailed. Under Microbiome First Medicine and considering the importance of keystone bacteria and critical windows of development, changes in even a few microbiota-prioritized medical decisions could make a significant difference in health across the life course.

Keywords

chronic disorders; inflammation; human superorganism; holobiont; microbiome; multimorbidity; microimmunosome; polypharmacy; drug safety; sustainable healthcare

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