Emerging Potential of Naturally Occurring Molecules against Gastric Cancer: Insights Molecular Mechanism and Therapeutic Targets

Seog Young Kang; Dongwon Hwang; Soyoung Shin; Jinju Park; Myoungchan Kim; MD. Hasanur Rahman; Md. Ataur Rahman; Seong-Gyu Ko; Bonglee Kim

doi:10.20944/preprints202107.0612.v1

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preprints.org > medicine and pharmacology > oncology and oncogenics > doi: 10.20944/preprints202107.0612.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Emerging Potential of Naturally Occurring Molecules against Gastric Cancer: Insights Molecular Mechanism and Therapeutic Targets

Version 1 : Received: 27 July 2021 / Approved: 27 July 2021 / Online: 27 July 2021 (22:20:18 CEST)

A peer-reviewed article of this Preprint also exists.

Kang, S.Y.; Hwang, D.; Shin, S.; Park, J.; Kim, M.; Rahman, M.H.; Rahman, M.A.; Ko, S.-G.; Kim, B. Potential of Bioactive Food Components against Gastric Cancer: Insights into Molecular Mechanism and Therapeutic Targets. Cancers 2021, 13, 4502. Kang, S.Y.; Hwang, D.; Shin, S.; Park, J.; Kim, M.; Rahman, M.H.; Rahman, M.A.; Ko, S.-G.; Kim, B. Potential of Bioactive Food Components against Gastric Cancer: Insights into Molecular Mechanism and Therapeutic Targets. Cancers 2021, 13, 4502.

Abstract

Gastric cancer, also known as stomach cancer, is a cancer which develops from the lining of the stomach. Accumulated evidences and epidemiological studies have been indicated that natural products play an important role in gastric cancer prevention and treatment, although its mechanism of action did not elucidate yet. Particularly, experimental studies have been showed that natural products displayed a protective effect against gastric cancer via numerous molecular mechanisms such as suppression of cell metastasis, anti-angiogenesis, inhibition of cell proliferation, induction of apoptosis, and modulation of autophagy. Although chemotherapy remains the standard treatment for advanced gastric cancer along with surgery, radiation therapy, hormone therapy and immunotherapy, but its adverse side effects including neutropenia, stomatitis, mucositis, diarrhea, nausea, and emesis are well documented. Additionally, intake of naturally occurring phytochemicals could increase the efficacy of gastric chemotherapy and chemotherapeutics resistance. However, natural product structural stability and powerful bioactivity are important to develop novel treatments for gastric cancer that may minimize such adverse effects. Therefore, the purpose of this review is to summarize the potential therapeutic effects of natural products on prevention and treatment of gastric cancer with intensive molecular mechanisms of action, bioavailability, and safety efficacy.

Keywords

Gastric cancer; natural products; autophagy; apoptosis; angiogenesis; metastasis; chemo-resistance.

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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