Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Assessment of a Nano-Docetaxel Combined Treatment for Head and Neck Cancer

Version 1 : Received: 24 July 2021 / Approved: 26 July 2021 / Online: 26 July 2021 (14:04:49 CEST)

A peer-reviewed article of this Preprint also exists.

Lee, G.Y.; Mubasher, M.; McKenzie, T.S.; Schmitt, N.C.; Sebelik, M.E.; Flanagan, C.E.; Osta, B.E.; Cothran, M.B.; Green, H.-N. Assessment of a Nano-Docetaxel Combined Treatment for Head and Neck Cancer. Onco 2021, 1, 83-94. Lee, G.Y.; Mubasher, M.; McKenzie, T.S.; Schmitt, N.C.; Sebelik, M.E.; Flanagan, C.E.; Osta, B.E.; Cothran, M.B.; Green, H.-N. Assessment of a Nano-Docetaxel Combined Treatment for Head and Neck Cancer. Onco 2021, 1, 83-94.

Journal reference: Onco 2021, 1, 7
DOI: 10.3390/onco1020007

Abstract

Objective: The combination of docetaxel (DTX) with Laser-Activated NanoTherapy (LANT), as a treatment for head and neck cancer (HNC) may enhance the therapeutic efficacy of lower doses of DTX, thereby minimizing the effective dosage, side effects and treatment times. Material and methods: Three HNSCC cell lines, Detroit 562, FaDu, and CAL 27, were treated with four combinations of DTX + LANT to evaluate DTX dose reduction and cell viability. Results: The 1 nM DTX + 5 nM LANT combination was the most effective treatment, increasing cell death over its corresponding DTX monotreatment with approximately 86.6%, 80.7%, and 92.1% cell death for Detroit 562, FaDu, and CAL 27, respectively. In Detroit 562, the 1 nM DTX + 5 nM LANT combination treatment resulted in the highest percentage of DTX dose reduction at 84.6%; in FaDu and CAL 27, the 0.5 nM DTX + 5 nM LANT combination treatment resulted in the highest percentage of DTX dose reduction at 78.2% and 82.4%, respectively. Conclusion: LANT may increase the therapeutic efficacy of DTX at significantly lower doses, which could improve patient outcomes.

Keywords

docetaxel; combination therapy; nanoparticles; head and neck squamous cell carcinoma; oncology; therapies

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