To realize precise control of single quantum dots (Qdots) device, the high-performance bias source play the key role. In this paper, the 16-channel high precision voltage bias source prototype for Qdots device with 18-bit resolution was designed. The prototype was made and its performance was tested. The short time fluctuations can reach 50μV. The up-step and the down-step response time can achieve less than 3μs. The stability, linearity and setting time of the bias source exhibits good performance. What's more, the voltage bias source can be controlled by local and online. The results show that it is one effective and feasible topology for the high precision voltage bias source in Qdots device application.