Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Risk Factors for Early and Late Onset Preeclampsia in Reunion island: Multivariate Analysis of Singleton and Twin Pregnancies. A 20-year Population-Based Cohort of 2120 Preeclampsia Cases

Version 1 : Received: 19 July 2021 / Approved: 20 July 2021 / Online: 20 July 2021 (09:44:40 CEST)

A peer-reviewed article of this Preprint also exists.

Robillard, P.-Y.; Boukerrou, M.; Dekker, G.; Scioscia, M.; Bonsante, F.; Boumahni, B.; Iacobelli, S. Risk Factors for Early and Late Onset Preeclampsia in Reunion Island: Multivariate Analysis of Singleton and Twin Pregnancies. A 20-Year Population-Based Cohort of 2120 Preeclampsia Cases. Reprod. Med. 2021, 2, 131-143. Robillard, P.-Y.; Boukerrou, M.; Dekker, G.; Scioscia, M.; Bonsante, F.; Boumahni, B.; Iacobelli, S. Risk Factors for Early and Late Onset Preeclampsia in Reunion Island: Multivariate Analysis of Singleton and Twin Pregnancies. A 20-Year Population-Based Cohort of 2120 Preeclampsia Cases. Reprod. Med. 2021, 2, 131-143.

Journal reference: Reprod. Med. 2021, 2, 14
DOI: 10.3390/reprodmed2030014

Abstract

Objectives: To develop a multivariate model for risk factors specific to early onset preeclampsia (EOP) and late onset preeclampsia (LOP) in our entire population (singleton and twin pregnancies). Material and methods: 20 year-observational population-based historical cohort study (2001-2020). All consecutive births delivered at the Centre Hospitalier Universitaire Hospitalier Sud Reunion’s maternity. A standardized validated epidemiological perinatal data base. Results: During the 20-year period, there were 81,834 pregnancies and 83,555 infants born, 1232 dichorionic and 350 monochorionic twin pregnancies. There were 2120 cases of preeclampsia, of which 2001preeclamptic singleton pregnancies and 119 twin pregnancies (incidence 7.5% in twin pregnancies vs 2.5% singletons, OR 3.0, p<0.001). Independent risk factors for EOP and LOP in a multivariate model (controlling for the two major confounders: namely maternal ages -both risks for EOP and LOP- and maternal pre-pregnancy BMI – specific risk factor for LOP) were: history of preeclampsia (aOR 11.7 for EOP, 7.8 for LOP, p < 0.0001), chronic hypertension (aOR 7.3 for EOP, 3.9 for LOP, p < 0.0001), history of perinatal death (aOR 2.2 for EOP, p < 0.0001 and 1.48 for LOP, p= 0.007), primipaternity (aOR 3.0 for EOP and 3.6 for LOP, p = 0.001), dizygotic twin pregnancies (aOR 3.7 for EOP, p < 0.0001 and 2.1 for LOP, p = 0.003), monozygotic twin pregnancies (aOR 3.98 for EOP, p = 0.003 and NS for LOP), ovulation induction (aOR 5.6 for EOP, p = 0.004 and NS for LOP), and in vitro fertilization (aOR 2.8 for EOP, p = 0.05 and NS for LOP). Specific to LOP and NS for EOP: renal diseases (aOR for LOP 2.9, p= 0.007) and gestational diabetes mellitus (aOR 1.2, p= 0.04). Conclusions: Maternal ages over 35 years, chronic hypertension , history of preeclampsia, ovulation induction, in vitro fertilizations, history of perinatal deaths and twin pregnancy (in our experience, especially mono zygotic twin pregnancies) are significant risk factors for EOP. New paternity is an independent factor for both EOP and LOP.

Keywords

Preeclampsia; epidemiology; early onset preeclampsia; late onset preeclampsia; twin pregnancies; monozygotic twins; dizygotic twins

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