Patterson, S.D.; Huang, X.; Jørgensen, H.G.; Michie, A.M. Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia. Hemato2021, 2, 556-572.
Patterson, S.D.; Huang, X.; Jørgensen, H.G.; Michie, A.M. Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia. Hemato 2021, 2, 556-572.
Patterson, S.D.; Huang, X.; Jørgensen, H.G.; Michie, A.M. Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia. Hemato2021, 2, 556-572.
Patterson, S.D.; Huang, X.; Jørgensen, H.G.; Michie, A.M. Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia. Hemato 2021, 2, 556-572.
Abstract
Acute myeloid leukemia (AML) is a hematological cancer with poor outcomes due to a lack of efficacious targeted therapies. The Nuclear Factor of Activated T Cells (NFAT) family of transcription factors is well characterized as a regulator of the cell cycle and differentiation in the myeloid lineage. Recent evidence has demonstrated that NFAT family members may have roles in regulating AML leukemogenesis and resistance to targeted therapy in myeloid leukemias. Furthermore gene expression data from patient samples show that some NFATs are more highly expressed in poorly differentiated AML and after disease relapse, implying that the NFAT family may have roles in specific types of AML. This review outlines the evidence for the role of NFAT in healthy myeloid tissue and explores how NFAT might regulate AML pathogenesis, highlighting the potential to target specific NFAT proteins therapeutically in AML.
Keywords
Leukemia; NFAT; Myeloid; Cell Cycle; Differentiation; AML
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
