Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Course-Based Undergraduate Research Experience on the Evolution of Antibiotic Resistance and its Molecular Basis

Version 1 : Received: 16 July 2021 / Approved: 19 July 2021 / Online: 19 July 2021 (15:47:18 CEST)

How to cite: Dickinson, K.; Mukerji, J.; Graham, S.; Warfield, L.; Kerr, B. A Course-Based Undergraduate Research Experience on the Evolution of Antibiotic Resistance and its Molecular Basis. Preprints 2021, 2021070420 (doi: 10.20944/preprints202107.0420.v1). Dickinson, K.; Mukerji, J.; Graham, S.; Warfield, L.; Kerr, B. A Course-Based Undergraduate Research Experience on the Evolution of Antibiotic Resistance and its Molecular Basis. Preprints 2021, 2021070420 (doi: 10.20944/preprints202107.0420.v1).

Abstract

Course-based Undergraduate Research Experiences (CUREs) in high-enrollment, introductory classes are a 37 potentially transformative approach to retaining more students in STEM majors. We developed and piloted a CURE 38 in the introductory biology courses at the University of Washington. This CURE focuses on analyzing experimental 39 evolution of antibiotic resistance in Escherichia coli and generates data on two topics relevant to clinical practice: 40 compensatory mutations and cross-drug effects. By studying mutations in central cellular machinery that confer drug 41 resistance, students not only gain insight into fundamental cellular phenomena, but also recognize the molecular 42 basis of a medically important form of evolutionary change, connecting genetics, microbiology, and evolution.

Supplementary and Associated Material

Keywords

CURE; undergraduate research; natural selection; experimental evolution; molecular biology; genetics; structure- 46 function relationships; introductory biology; laboratory exercise

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