Version 1
: Received: 16 July 2021 / Approved: 19 July 2021 / Online: 19 July 2021 (15:47:18 CEST)
How to cite:
Dickinson, K.; Mukerji, J.; Graham, S.; Warfield, L.; Kerr, B. A Course-Based Undergraduate Research Experience on the Evolution of Antibiotic Resistance and its Molecular Basis. Preprints2021, 2021070420. https://doi.org/10.20944/preprints202107.0420.v1
Dickinson, K.; Mukerji, J.; Graham, S.; Warfield, L.; Kerr, B. A Course-Based Undergraduate Research Experience on the Evolution of Antibiotic Resistance and its Molecular Basis. Preprints 2021, 2021070420. https://doi.org/10.20944/preprints202107.0420.v1
Dickinson, K.; Mukerji, J.; Graham, S.; Warfield, L.; Kerr, B. A Course-Based Undergraduate Research Experience on the Evolution of Antibiotic Resistance and its Molecular Basis. Preprints2021, 2021070420. https://doi.org/10.20944/preprints202107.0420.v1
APA Style
Dickinson, K., Mukerji, J., Graham, S., Warfield, L., & Kerr, B. (2021). A Course-Based Undergraduate Research Experience on the Evolution of Antibiotic Resistance and its Molecular Basis. Preprints. https://doi.org/10.20944/preprints202107.0420.v1
Chicago/Turabian Style
Dickinson, K., Liz Warfield and Ben Kerr. 2021 "A Course-Based Undergraduate Research Experience on the Evolution of Antibiotic Resistance and its Molecular Basis" Preprints. https://doi.org/10.20944/preprints202107.0420.v1
Abstract
Course-based Undergraduate Research Experiences (CUREs) in high-enrollment, introductory classes are a 37 potentially transformative approach to retaining more students in STEM majors. We developed and piloted a CURE 38 in the introductory biology courses at the University of Washington. This CURE focuses on analyzing experimental 39 evolution of antibiotic resistance in Escherichia coli and generates data on two topics relevant to clinical practice: 40 compensatory mutations and cross-drug effects. By studying mutations in central cellular machinery that confer drug 41 resistance, students not only gain insight into fundamental cellular phenomena, but also recognize the molecular 42 basis of a medically important form of evolutionary change, connecting genetics, microbiology, and evolution.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
