Review
Version 1
Preserved in Portico This version is not peer-reviewed
Synthetic mRNAs; Their Analogue Caps and Contribution to Disease
Version 1
: Received: 17 July 2021 / Approved: 19 July 2021 / Online: 19 July 2021 (10:41:42 CEST)
A peer-reviewed article of this Preprint also exists.
Kyriakopoulos, A.M.; McCullough, P.A. Synthetic mRNAs; Their Analogue Caps and Contribution to Disease. Diseases 2021, 9, 57. Kyriakopoulos, A.M.; McCullough, P.A. Synthetic mRNAs; Their Analogue Caps and Contribution to Disease. Diseases 2021, 9, 57.
Abstract
The structure of synthetic mRNAs as used in vaccination against cancer and infectious diseases contain specifically designed caps followed by sequences of the 5’ untranslated repeats of β-globin gene. The strategy for successful design of synthetic mRNAs by chemically modifying their caps aims to increase resistance to the enzymatic deccapping complex, offer a higher affinity for binding to the eukaryotic translation initiation factor 4E (elF4E) protein and enforce increased translation of their encoded proteins. However, the cellular homeostasis is finely balanced and obeys to specific laws of thermodynamics conferring balance between complexity and growth rate in evolution. An overwhelming and forced translation even under alarming conditions of the cell during a concurrent viral infection, or when molecular pathways are trying to circumvent precursor events that lead to autoimmunity and cancer, may cause the recipient cells to ignore their differential sensitivities which are essential for keeping normal conditions. The elF4E which is a powerful RNA regulon and a potent oncogene governing cell cycle progression and proliferation at a post-transcriptional level, may then be a great contributor to disease development. The mechanistic target of rapamycin (mTOR) axis manly inhibits the elF4E to proceed with mRNA translation but disturbance in fine balances between mTOR and elF4E action may provide a premature step towards oncogenesis, ignite pre-causal mechanisms of immune deregulation and cause maturation (aging) defects.
Keywords
synthetic mRNA; analogue caps; elF4E; mTORC1; autophagy: immunity deregulation; maturation defects; autoimmunity; cancer
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
