Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Lynch Syndrome: Current Status of CRC in Biotechnological and Biomedical Fields

Version 1 : Received: 12 July 2021 / Approved: 13 July 2021 / Online: 13 July 2021 (11:27:16 CEST)
Version 2 : Received: 12 August 2021 / Approved: 12 August 2021 / Online: 12 August 2021 (12:20:49 CEST)

How to cite: Capuzzo, A.M. Lynch Syndrome: Current Status of CRC in Biotechnological and Biomedical Fields. Preprints 2021, 2021070303 (doi: 10.20944/preprints202107.0303.v2). Capuzzo, A.M. Lynch Syndrome: Current Status of CRC in Biotechnological and Biomedical Fields. Preprints 2021, 2021070303 (doi: 10.20944/preprints202107.0303.v2).

Abstract

Lynch syndrome (LS) is an autosomal dominant genetic condition caused by mutations in the DNA mismatch repair (MMR) genes in the germline. Colorectal cancer and/or LS-associated cancer are more likely in people who carry pathogenic mutations in these genes. Cancers of the endometrium, small intestine, stomach, pancreas, and biliary tract, ovarian, brain, upper urinary tract, and skin are among the cancer types linked to LS. The criteria for a clinical diagnosis of LS, as well as the processes for genetic testing to identify carriers of pathogenetic mutations in MMR genes, have been known for a long time. The precise description of the pathogenicity associated with MMR genetic variants is critical in the mutation detection analysis, especially in order to enroll mutation carriers in endoscopic surveillance programs that are more suited to them. As a result, this may aid in the improvement of LS-related cancer prevention efforts. In this review, we discuss recent advances in the molecular genetics of LS.

Keywords

Lynch syndrome; CRC; Cancer; Biotechnology; Biomedical

Comments (1)

Comment 1
Received: 12 August 2021
Commenter: Arnaud Martino Capuzzo
Commenter's Conflict of Interests: Author
Comment: Adding fig.1
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