Version 1
: Received: 25 June 2021 / Approved: 2 July 2021 / Online: 2 July 2021 (11:34:47 CEST)
How to cite:
Fekete, Z.; Terțan, B.O.; Ráduly, L.; Eniu, D.T.; Buiga, R.; Galatâr, M.; Berindan-Neagoe, I. MMTV Prevalence in Breast Cancer Samples in Romania- Do Major Geographical Differences Exist in the World Population?. Preprints2021, 2021070050. https://doi.org/10.20944/preprints202107.0050.v1
Fekete, Z.; Terțan, B.O.; Ráduly, L.; Eniu, D.T.; Buiga, R.; Galatâr, M.; Berindan-Neagoe, I. MMTV Prevalence in Breast Cancer Samples in Romania- Do Major Geographical Differences Exist in the World Population?. Preprints 2021, 2021070050. https://doi.org/10.20944/preprints202107.0050.v1
Fekete, Z.; Terțan, B.O.; Ráduly, L.; Eniu, D.T.; Buiga, R.; Galatâr, M.; Berindan-Neagoe, I. MMTV Prevalence in Breast Cancer Samples in Romania- Do Major Geographical Differences Exist in the World Population?. Preprints2021, 2021070050. https://doi.org/10.20944/preprints202107.0050.v1
APA Style
Fekete, Z., Terțan, B.O., Ráduly, L., Eniu, D.T., Buiga, R., Galatâr, M., & Berindan-Neagoe, I. (2021). MMTV Prevalence in Breast Cancer Samples in Romania- Do Major Geographical Differences Exist in the World Population?. Preprints. https://doi.org/10.20944/preprints202107.0050.v1
Chicago/Turabian Style
Fekete, Z., Mihaela Galatâr and Ioana Berindan-Neagoe. 2021 "MMTV Prevalence in Breast Cancer Samples in Romania- Do Major Geographical Differences Exist in the World Population?" Preprints. https://doi.org/10.20944/preprints202107.0050.v1
Abstract
(1) Background: Mouse-mammary tumor virus (MMTV) might play a role in the etiology of some breast cancers in humans. The purpose of our study was to identify MMTV DNA sequences in breast tissue samples from breast cancer patients operated in our regional center from Romania. (2) Methods: We have selected 75 patients with non-metastatic breast cancer treated with curative intent and searched with PCR the MMTV-like DNA sequence in the breast cancer tissue and normal breast tissue obtained from the same patients. (3) Results: None of the examined samples was positive for MMTV-like target sequences on PCR. (4) Conclusions: We could not prove that MMTV plays a role in the etiology of breast cancer in our patient group. This finding is similar to findings of other geographically related research groups and might be due to the fact that only the Mus musculus domesticus mouse species was proven to carry infectious MMTV, but not the Mus musculus musculus species, which is specific to South-Eastern Europe and some parts of Asia.
Keywords
mouse mammary tumor virus 1; human breast cancer 2; risk factor 3
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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