The Ryanodine Receptor as a Sensor for Cellular Environments in Muscles

Takuya Kobayashi; Nagomi Kurebayashi; Takashi Murayama

doi:10.20944/preprints202106.0692.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 28 June 2021 / Approved: 29 June 2021 / Online: 29 June 2021 (08:37:53 CEST)

The ryanodine receptor (RyR) is a Ca2+ release channel in the sarcoplasmic reticulum of skeletal and cardiac muscles and plays a key role in excitation-contraction coupling. The activity of the RyR is regulated by many intracellular factors such as divalent cations (Ca2+ and Mg2+), nucleotides, associated proteins, and reactive oxygen species. Since these intracellular factors change depending on the condition of the muscle, e.g., exercise, fatigue, or disease states, the RyR channel activity will be altered accordingly. In this review, we describe how the RyR channel is regulated under various conditions and discuss the possibility that the RyR acts as a sensor for change in the cellular environment of muscles.

Ryanodine receptor; skeletal muscle; cardiac muscle; exercise and injury; heart function; diet

Biology and Life Sciences, Anatomy and Physiology

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The Ryanodine Receptor as a Sensor for Cellular Environments in Muscles

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