Working Paper Review Version 1 This version is not peer-reviewed

Mathematical Models for FDG Kinetics in Cancer: A Review

Version 1 : Received: 27 June 2021 / Approved: 29 June 2021 / Online: 29 June 2021 (08:34:49 CEST)

A peer-reviewed article of this Preprint also exists.

Sommariva, S.; Caviglia, G.; Sambuceti, G.; Piana, M. Mathematical Models for FDG Kinetics in Cancer: A Review. Metabolites 2021, 11, 519. Sommariva, S.; Caviglia, G.; Sambuceti, G.; Piana, M. Mathematical Models for FDG Kinetics in Cancer: A Review. Metabolites 2021, 11, 519.

Journal reference: Metabolites 2021, 11, 519
DOI: 10.3390/metabo11080519

Abstract

Compartmental analysis is the mathematical framework for the modelling of tracer kinetics in dynamical Positron Emission Tomography. This paper provides a review of how compartmental models are constructed and numerically optimized. Specific focus is given on the identifiability and sensitivity issues and on the impact of complex physiological conditions on the mathematical properties of the models.

Keywords

Positron Emission Tomography (PET); FDG; tracer kinetics; compartmental analysis

Subject

LIFE SCIENCES, Biochemistry

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