Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Review Article About Superbug Fungus C. auris

Version 1 : Received: 22 June 2021 / Approved: 24 June 2021 / Online: 24 June 2021 (11:54:40 CEST)

How to cite: Malik, T.; Mazhar, E.; Khan, K.H.; Hussain, S. Review Article About Superbug Fungus C. auris. Preprints 2021, 2021060603 (doi: 10.20944/preprints202106.0603.v1). Malik, T.; Mazhar, E.; Khan, K.H.; Hussain, S. Review Article About Superbug Fungus C. auris. Preprints 2021, 2021060603 (doi: 10.20944/preprints202106.0603.v1).

Abstract

The newly emerging nosocomial pathogen Candida auris is linked with persistent hospital-acquired infections and abrupt outbreaks across six continents. Genotypic analysis is indicative of the appearance of independent distinct clades of this particular fungus in different geographic locations simultaneously. Intrusive deep seated infections in addition to colonization have been diagnosed primarily in hospitalized patients and have drawn a lot of attention because of different antifungal susceptibility profiles and transmission despite strict preventive measures. Problems with the accurate identification of C. auris using phenotypic and molecular approaches has raised concerns about the detection of relevant levels of the problem. Candida family associated infections are a serious causative agent of mortality and morbidity in immune-compromised individuals. Candida auris are also known as superbug fungus that spreads rapidly all over the world. In 2009, shortly after the first case, various strains across the six continents have been recognized as nosocomial pathogens. Simultaneous and independent C. auris outbreaks appear to be of great concern for the healthcare settings as well as scientific community. Additionally, microbiological misidentification and multidrug resistance, rarely noticed for other non-albicans Candida species, lead to problems in obliteration and frequent treatment failures for C. auris infections. This review article aims to provide a comprehensive and up to date report on the global C. auris outbreaks, considering clinical along with microbiological characteristics, virulence mechanisms and susceptibility to antifungals, as well as the effectiveness of available preventive and therapeutic implementations.

Subject Areas

Candida auris; Superbug fungus; biofilm; Candida albicans; nosocomial infection; Candidiasis

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