Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Biocompatibility and Antibacterial Properties of TiCu(Ag) Thin Films Produced by Physical Vapor Deposition Magnetron Sputtering

Saqib Rashid
* ,
Gian Marco Vita
,
Luca Persichetti
ORCID logo ,
Giovanna Iucci
ORCID logo ,
Chiara Battocchio
ORCID logo ,
Rostislav Daniel
,
Daniela Visaggio
,
Martina Marsotto
,
Paolo Visca
ORCID logo ,
Edoardo Bemporad
,
Paolo Ascenzi
,
Giovanni Capellini
,
Marco Sebastiani
,
Alessandra Di Masi
* ORCID logo
Version 1 : Received: 22 June 2021 / Approved: 24 June 2021 / Online: 24 June 2021 (11:04:43 CEST)

How to cite: Rashid, S.; Vita, G.M.; Persichetti, L.; Iucci, G.; Battocchio, C.; Daniel, R.; Visaggio, D.; Marsotto, M.; Visca, P.; Bemporad, E.; Ascenzi, P.; Capellini, G.; Sebastiani, M.; Di Masi, A. Biocompatibility and Antibacterial Properties of TiCu(Ag) Thin Films Produced by Physical Vapor Deposition Magnetron Sputtering. Preprints 2021, 2021060601. https://doi.org/10.20944/preprints202106.0601.v1 Rashid, S.; Vita, G.M.; Persichetti, L.; Iucci, G.; Battocchio, C.; Daniel, R.; Visaggio, D.; Marsotto, M.; Visca, P.; Bemporad, E.; Ascenzi, P.; Capellini, G.; Sebastiani, M.; Di Masi, A. Biocompatibility and Antibacterial Properties of TiCu(Ag) Thin Films Produced by Physical Vapor Deposition Magnetron Sputtering. Preprints 2021, 2021060601. https://doi.org/10.20944/preprints202106.0601.v1

Abstract

Mechanical robustness, biocompatibility, and antibacterial performances are key features for materials suitable to be used in tissue engineering applications. In this work, we investigated the link existing between structural and functional properties of TiCu(Ag) thin films deposited by physical vapor deposition magnetron sputtering on Si substrates. The thin films were characterized by X-ray diffraction (XRD), nanoindentation, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). The TiCu(Ag) thin films showed complete amorphous structure and improved mechanical properties in comparison with pure Ti films. However, for contents in excess of 20% Ag, we observed the appearance of nanometric Ag crystallite. The TiCu(Ag) thin films displayed excellent biocompatibility properties, allowing adhesion and proliferation of the human fibroblasts MRC-5 cell line. Moreover, all the investigated TiCu(Ag) alloy display bactericidal properties, preventing the growth of both Pseudomonas aeruginosa and Staphylococcus aureus. Results obtained from biological tests have been correlated to the surface structure and microstructure of films. The excellent biocompatibility and bactericidal properties of these multifunctional thin films opens to their use in tissue engineering applications.

Keywords

bactericidal; biocompatibility; copper; human fibroblast; physical vapor deposition (PVD); silver; titanium; thin films

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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