Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Elevated Brachial-Ankle Pulse Wave Velocity Is Associated With an Increase of Left Ventricular Mass Index in Hypertensive Patients

Version 1 : Received: 22 June 2021 / Approved: 24 June 2021 / Online: 24 June 2021 (08:39:17 CEST)

How to cite: Fajarwati, D.; Pikir, B.S.; Muhammad, R.; Mulia, E.P.B. Elevated Brachial-Ankle Pulse Wave Velocity Is Associated With an Increase of Left Ventricular Mass Index in Hypertensive Patients. Preprints 2021, 2021060592 (doi: 10.20944/preprints202106.0592.v1). Fajarwati, D.; Pikir, B.S.; Muhammad, R.; Mulia, E.P.B. Elevated Brachial-Ankle Pulse Wave Velocity Is Associated With an Increase of Left Ventricular Mass Index in Hypertensive Patients. Preprints 2021, 2021060592 (doi: 10.20944/preprints202106.0592.v1).

Abstract

Background: Brachial-ankle pulse wave velocity (baPWV) is widely used as a marker of arterial stiffness. It has been suggested as a simple method for detecting arterial loads that can trigger left ventricular hypertrophy in the heart. Increased left ventricular hypertrophy in hypertensive patients is a predictor that will have an impact on increasing morbidity and mortality. Objective: This study aimed to evaluate the correlation between the baPWV and the left ventricular mass index (LVMI) in hypertensive patients. Methods: This cross-sectional study was conducted by collecting secondary data from hypertensive patients at the Heart Outpatient Clinic, with inclusion: aged more than 40 years old, suffering hypertension more than one year, and had baPWV and echocardiography data. Correlation between baPWV and LVMI was evaluated using the Pearson correlation test. Results: A total of 40 hypertensive patients were enrolled in this study. 60% were women. The mean age was 52.92 ± 9.50 years. Mean LVMI was 107.20 + 21.01 gram/m2. LVMI showed a significant association with age and systolic blood pressure (p=0.001 and 0.019, respectively). Mean baPWV was 1832.90 + 336.22 cm/sec. A significant association was found between baPWV and age and systolic blood pressure (p=0.000 and 0.049, respectively). There was a significant positive correlation between baPWV and LVMI (r=0.493, p=0.001); and between baPWV and Relative Wall Thickness (RWT) (r=0.404, p=0.01). Conclusion: This study shows that elevated baPWV is an indicator of increased LVMI in hypertensive patients. Examination of baPWV should be carried out routinely to detect earlier arterial stiffness as a morbidity and mortality prevention strategy in hypertensive patients.

Keywords

arterial stiffness; brachial-ankle pulse wave velocity; left ventricular mass index; echocardiography; hypertension

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