Working Paper Article Version 1 This version is not peer-reviewed

The Use of Turmeric as an Analgesic Using the Formalin Test in Murine Model

Version 1 : Received: 12 June 2021 / Approved: 15 June 2021 / Online: 15 June 2021 (11:58:18 CEST)

How to cite: Mayorga, E.A.G.; Didier, L.G.A.; Lizbeth, R.A.L.; Nora, D.L.F.D.L.T.; Patricia, C.L.M.; Lorena, Á.C. The Use of Turmeric as an Analgesic Using the Formalin Test in Murine Model. Preprints 2021, 2021060402 Mayorga, E.A.G.; Didier, L.G.A.; Lizbeth, R.A.L.; Nora, D.L.F.D.L.T.; Patricia, C.L.M.; Lorena, Á.C. The Use of Turmeric as an Analgesic Using the Formalin Test in Murine Model. Preprints 2021, 2021060402

Abstract

Abstract: Turmeric is a plant with multiple medicinal attributes. One of them being its analgesic effect. In this project the analgesic effect of the plant was evaluated with an inflammatory pain model: the 5% formalin model. Turmeric was administered to 250 g male Wistar rats (6 ± 2) provided by the Health Science department’s vivarium. The dose-response curve of the plant was per-formed observing the analgesic effect. Once the dose was selected, they were administrated within different turmeric protocols. 400 mg orally every 24 h for two weeks, another group with turmeric ad libitum for two weeks, the control group with 0.9% saline solution for two weeks, and a group with administration of metamizole prior to evaluation with 5% formalin. Subsequently, each rat was evaluated by 5% formalin intraplantarly and the number of rat paw twitches per 1 h was observed. The analysis of the data generated through the obtained results was carried out. The dose of 400 mg of oral turmeric was administered for two weeks without observing any collateral effects. An excellent analgesic effect was found in this protocol, as well as, in the ad libitum administration for two weeks compared to the control group. Likewise, turmeric presents a milder effect than metamizole, a well-known analgesic.

Keywords

turmeric longa, analgesia, 5% formalin

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