PreprintReviewVersion 1Preserved in Portico This version is not peer-reviewed
A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, their Risks and How an Alternate RBD Vaccine is Safer?
Version 1
: Received: 13 June 2021 / Approved: 14 June 2021 / Online: 14 June 2021 (15:41:00 CEST)
Version 2
: Received: 22 June 2021 / Approved: 22 June 2021 / Online: 22 June 2021 (11:53:34 CEST)
How to cite:
Jahangir, Z.S.; Marnik, A.H. A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, their Risks and How an Alternate RBD Vaccine is Safer?. Preprints2021, 2021060377. https://doi.org/10.20944/preprints202106.0377.v1
Jahangir, Z.S.; Marnik, A.H. A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, their Risks and How an Alternate RBD Vaccine is Safer?. Preprints 2021, 2021060377. https://doi.org/10.20944/preprints202106.0377.v1
Jahangir, Z.S.; Marnik, A.H. A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, their Risks and How an Alternate RBD Vaccine is Safer?. Preprints2021, 2021060377. https://doi.org/10.20944/preprints202106.0377.v1
APA Style
Jahangir, Z.S., & Marnik, A.H. (2021). A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, their Risks and How an Alternate RBD Vaccine is Safer?. Preprints. https://doi.org/10.20944/preprints202106.0377.v1
Chicago/Turabian Style
Jahangir, Z.S. and Arleta Helena Marnik. 2021 "A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, their Risks and How an Alternate RBD Vaccine is Safer?" Preprints. https://doi.org/10.20944/preprints202106.0377.v1
Abstract
The SARS (severe acute respiratory syndrome)-CoV (Coronavirus)-2 S(spike)-protein mRNA/cDNA currently being used as vaccines are antigenic but not antigens against SARS-CoV-2, that causes COVID (Coronavirus Disease) -19. Furthermore, the mRNA and cDNA antigenic vaccines also have potentials for homologous as well as heterologous recombination, primarily into the somatic cell DNA of the vaccine recipients. On the contrary, a SARS-CoV-2 RBD-protein antigen, a part of the S-protein, will directly stimulate antibody production against SARS-CoV-2. Hence, a vaccine composed of SARS-CoV-2 RBD-protein as a safer, fast acting, and effective vaccine against SARS-CoV-2 and thus against COVID-19. This is also useful for some immune compromised individuals.
Keywords
aa = amino acids, ACE-2 = receptor angiotensin-converting enzyme 2, cDNA = complementary DNA, mRNA = messenger RNA, orf = open reading frame, RBD = receptor binding protein
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
