A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, their Risks and How an Alternate RBD Vaccine is Safer?

Z.M.G. Sarwar Jahangir; Arleta Helena Marnik

doi:10.20944/preprints202106.0377.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 13 June 2021 / Approved: 14 June 2021 / Online: 14 June 2021 (15:41:00 CEST)
Version 2 : Received: 22 June 2021 / Approved: 22 June 2021 / Online: 22 June 2021 (11:53:34 CEST)

The SARS (severe acute respiratory syndrome)-CoV (Coronavirus)-2 S(spike)-protein mRNA/cDNA currently being used as vaccines are antigenic but not antigens against SARS-CoV-2, that causes COVID (Coronavirus Disease) -19. Furthermore, the mRNA and cDNA antigenic vaccines also have potentials for homologous as well as heterologous recombination, primarily into the somatic cell DNA of the vaccine recipients. On the contrary, a SARS-CoV-2 RBD-protein antigen, a part of the S-protein, will directly stimulate antibody production against SARS-CoV-2. Hence, a vaccine composed of SARS-CoV-2 RBD-protein as a safer, fast acting, and effective vaccine against SARS-CoV-2 and thus against COVID-19. This is also useful for some immune compromised individuals.

aa = amino acids, ACE-2 = receptor angiotensin-converting enzyme 2, cDNA = complementary DNA, mRNA = messenger RNA, orf = open reading frame, RBD = receptor binding protein

BIOLOGY, Anatomy & Morphology

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A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, their Risks and How an Alternate RBD Vaccine is Safer?

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