PreprintReviewVersion 2Preserved in Portico This version is not peer-reviewed
A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, Their Risks and how an Alternate RBD Vaccine is Safer?
Version 1
: Received: 13 June 2021 / Approved: 14 June 2021 / Online: 14 June 2021 (15:41:00 CEST)
Version 2
: Received: 22 June 2021 / Approved: 22 June 2021 / Online: 22 June 2021 (11:53:34 CEST)
How to cite:
Jahangir, Z.S.; Marnik, A.H. A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, Their Risks and how an Alternate RBD Vaccine is Safer?. Preprints2021, 2021060377 (doi: 10.20944/preprints202106.0377.v2).
Jahangir, Z.S.; Marnik, A.H. A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, Their Risks and how an Alternate RBD Vaccine is Safer?. Preprints 2021, 2021060377 (doi: 10.20944/preprints202106.0377.v2).
Cite as:
Jahangir, Z.S.; Marnik, A.H. A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, Their Risks and how an Alternate RBD Vaccine is Safer?. Preprints2021, 2021060377 (doi: 10.20944/preprints202106.0377.v2).
Jahangir, Z.S.; Marnik, A.H. A Review of SARS-CoV-2, Responsible for COVID-19: History, Biology, Infection Mechanism, Antigenic Vaccines, Their Risks and how an Alternate RBD Vaccine is Safer?. Preprints 2021, 2021060377 (doi: 10.20944/preprints202106.0377.v2).
Abstract
The SARS (severe acute respiratory syndrome)-CoV (Coronavirus)-2 S(spike)-protein mRNA/cDNA currently being used as vaccines are antigenic but not antigens against SARS-CoV-2, that causes COVID (Coronavirus Disease) -19. Furthermore, the mRNA and cDNA antigenic vaccines also have potentials for homologous as well as heterologous recombination, primarily into the somatic cell DNA of the vaccine recipients. On the contrary, a SARS-CoV-2 RBD-protein antigen, a part of the S-protein, will directly stimulate antibody production against SARS-CoV-2. Hence, a vaccine composed of SARS-CoV-2 RBD-protein as a safer, fast acting, and effective vaccine against SARS-CoV-2 and thus against COVID-19. This is also useful for some immune compromised individuals.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: ZMG Sarwar Jahangir
Commenter's Conflict of Interests: Author