Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Viral Toxin ns1 as Pivotal Target in Development of Efficient Dengue Vaccine

Grégorie Lebeau
,
Alisé Lagrave
,
Eva Ogire
,
Lauriane Grondin
,
Soundary Seriacaroupin
,
Cédric Moutoussamy
,
Patrick Mavingui
,
Jean-jacques Hoarau
ORCID logo ,
Marjolaine Roche
,
Pascale Krejbich-trotot
ORCID logo ,
Philippe Desprès
* ORCID logo ,
Wildriss Viranaicken
* ORCID logo
Version 1 : Received: 7 June 2021 / Approved: 8 June 2021 / Online: 8 June 2021 (13:10:53 CEST)

A peer-reviewed article of this Preprint also exists.

Lebeau, G.; Lagrave, A.; Ogire, E.; Grondin, L.; Seriacaroupin, S.; Moutoussamy, C.; Mavingui, P.; Hoarau, J.-J.; Roche, M.; Krejbich-Trotot, P.; Desprès, P.; Viranaicken, W. Viral Toxin NS1 Implication in Dengue Pathogenesis Making It a Pivotal Target in Development of Efficient Vaccine. Vaccines 2021, 9, 946. Lebeau, G.; Lagrave, A.; Ogire, E.; Grondin, L.; Seriacaroupin, S.; Moutoussamy, C.; Mavingui, P.; Hoarau, J.-J.; Roche, M.; Krejbich-Trotot, P.; Desprès, P.; Viranaicken, W. Viral Toxin NS1 Implication in Dengue Pathogenesis Making It a Pivotal Target in Development of Efficient Vaccine. Vaccines 2021, 9, 946.

Abstract

Mosquito-borne viral disease dengue is a global public health problem causing a wide spectrum of clinical manifestations ranging from mild dengue fever to severe dengue with plasma leakage and bleeding which are often associated to fatality. To date, there are no specific medications to treat dengue and prevent the risk of hemorrhage. Dengue is caused by one of the four related antigenically distinct serotypes, DENV-1 to DENV-4. The growing burden that represents the four DENV serotypes has intensified both basic and applied researches to better understand the dengue physiopathology. It has been proposed a significant role for the secreted soluble DENV nonstructural protein 1 (sNS1) glycoprotein in the pathogenesis of severe dengue. Here, we provided an overview on current knowledge about the role of sNS1 in the immunopathogenesis of dengue disease. The reasons for the consideration of sNS1 in the design of future dengue vaccine candidates will be discussed.

Keywords

arbovirus, dengue, viral hemorrhagic fever, viral immunopathogenesis, viral toxin, NS1, dengue vaccine strategies

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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