Preprint Hypothesis Version 2 Preserved in Portico This version is not peer-reviewed

Cell Fusion as a Link between the SARS-CoV-2 Spike Protein, COVID-19 Complications, and Vaccine Side Effects

Version 1 : Received: 2 June 2021 / Approved: 4 June 2021 / Online: 4 June 2021 (08:21:00 CEST)
Version 2 : Received: 7 September 2021 / Approved: 9 September 2021 / Online: 9 September 2021 (10:54:14 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: Oncotarget 2021
DOI: 10.18632/oncotarget.28088


A distinctive feature of the SARS-CoV-2 spike protein is its ability to efficiently fuse cells, thus producing syncytia found in COVID-19 patients. This commentary proposes how this ability enables spike to cause COVID-19 complications as well as side effects of COVID-19 vaccines, and suggests how these effects can be prevented..


cell fusion; syncytia; cell hybrids; viruses; coronaviruses; SARS-CoV-2; COVID-19; fusogens; blood coagulation cascade; thrombosis, cancer; vaccines; neurological complications

Comments (1)

Comment 1
Received: 9 September 2021
Commenter: Yuri Lazebnik
Commenter's Conflict of Interests: Author
Comment: Dear Ediors,

I have added a section on neurological complications, expanded the section on vaccines, and edited the text to incorporate comments and suggestions that I have received after posting the original paper and to make the text clearer. Finally, I have made the title more specific and expanded the abstract as it was too terse to be informative.

Thank you.


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